DC-EEG discloses prominent, very slow activity patterns during sleep in preterm infants
DC-EEG discloses prominent, very slow activity patterns during sleep in preterm infants
复制标题
DOI：
10.1016/s1388-2457(02)00292-4
复制
发表时间：
2002-11-01
影响因子：
4.7
通讯作者：
Kaila, K
中科院分区：
文献类型：
--
作者：
Vanhatalo, S;Tallgren, P;Kaila, K
目的：本研究的目的是检验未成熟的人脑表现出，，慢电活动，而不是检测到的常规（即高通滤波）脑电图（EEG）的假设：6个健康的早产儿（孕龄33-37周）床边记录与直流（DC）脑电图在睡眠期间。选择安静睡眠的时段研究不连续FEG模式中的δ频率爆发（轨迹、不连续或轨迹交替），我们比较了未经滤波获得的波形（即真正的DC-EEG）与高通滤波后看到的那些相同的痕迹。在所有婴儿中，DC-EEG显示典型的δ频率爆发，，一直嵌入在哭大振幅（200-700 μ V）和持续时间长（1-5 s）的枕部负瞬变，这在常规EEG中是看不到的。我们的研究表明，（i）睡眠中的早产儿最突出的自发EEG活动包括非常缓慢，大幅度的瞬变，（ii）这些瞬变的最显著特征，在传统EEG中看不到。通过DC-EEG正确记录这种类型的脑活动为无创评估新生儿脑功能提供了一种新的方法。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Objectives: The objective of this study is to test the hypothesis that the immature human brain exhibit,, slow electrical activity that is not detected by conventional (i.e. high-pass filtered) electroencephalography (EEG).Methods: Six healthy preterm infants (conceptional age 33-37 weeks) were recorded bedside with direct current (DC) EEG during sleep. Epochs with quiet sleep were selected to study the delta frequency bursts during discontinuous FEG patterns (tract, discontinu or trace alternant), and we compared the waveforms obtained without filtering (i.e. genuine DC-EEG) to those seen after high pass filtering of the same traces.Results: In all infants, DC-EEG demonstrated that the typical delta frequency burst,, are consistently embedded in cry large amplitude (200-700 muV) and long lasting (1-5 s) occipitally negative transients, which are not seen in conventional EEG.Conclusions and significance: Our study demonstrates that (i) the most prominent spontaneous EEG activity of a sleeping preterm infant consists of very slow, large amplitude transients, and (ii) the most salient features of these transient,, are not seen in conventional EEG. Proper recording of this type of brain activity by DC-EEG provides a novel way for non-invasive assessment of neonatal brain function. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.