Sleep properties of CS mice with spontaneous rhythm splitting in constant darkness
Sleep properties of CS mice with spontaneous rhythm splitting in constant darkness
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DOI：
10.1016/s0006-8993(03)02947-0
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发表时间：
2003-08-01
期刊：
影响因子：
2.9
通讯作者：
Yoshimura, T
中科院分区：
文献类型：
--
作者：
Ebihara, S;Miyazaki, S;Yoshimura, T
在小鼠中，近交系之间的遗传差异已被证明是睡眠和昼夜活动节律的几个参数。我们的前期研究表明，CS小鼠的运动活动具有三个显著的昼夜节律特征：（1）白天和夜晚都有较高的活动量，（2）自由奔跑期不稳定，（3）自发节律分裂。为了表征CS小鼠的睡眠特性，我们将CS小鼠的昼夜睡眠模式与具有正常昼夜活动节律的C57 BL/6 J和C3 H/He小鼠的昼夜睡眠模式进行了比较。尽管C57 BL/6 J和C3 H/He小鼠在每个睡眠参数（清醒、SWS、PS）的量方面表现出清晰的每日睡眠-清醒节律，但CS小鼠在这些参数方面没有表现出清晰的节律。PS的差异尤其明显; CS小鼠的PS量、PS计数和PS间隔（连续PS发作之间的间隔）没有明显的昼夜差异。此外，CS小鼠的PS占总睡眠时间的比例显著大于其他品系。在这些参数中，最重要的是PS潜伏期，其极短，并且在这些小鼠中经常发生从清醒到PS的直接转变而不出现SWS。这些结果表明，CS小鼠可能有助于了解睡眠机制及其功能障碍。(C)2003 Elsevier B. V.保留所有权利。
In mice, genetic differences between inbred strains have been shown for several parameters of sleep and circadian activity rhythms. Our previous studies have demonstrated that CS mice have three remarkable characteristics in the circadian rhythm of locomotor activity: (1) high activity both during the day and night, (2) unstable freerunning period and (3) spontaneous rhythm splitting. In order to characterize sleep properties of CS mice, we compared circadian sleep patterns of CS with those of C57BL/6J and C3H/He mice which have normal circadian activity rhythms. Although C57BL/6J and C3H/He mice exhibited clear daily sleep-wake rhythms in the amount of each sleep parameter (Awake, SWS, PS), CS mice did not show clear rhythms in these parameters. The differences were particularly conspicuous in PS; no apparent day-night differences in the amount of PS, PS counts and PS interval (the interval between successive PS episodes) in CS mice. In addition, the ratio of PS to total sleep time was significantly larger in CS mice than other strains. Of these parameters, the most considerable was PS latency which was extremely short and direct transition from Awake to PS without appearance of SWS frequently occurred in these mice. These results indicate that CS mice may be useful for the understanding of sleep mechanisms and its dysfunction. (C) 2003 Elsevier B.V. All rights reserved.