Well-ordered mesoporous bioactive glasses (MBG): A promising bioactive drug delivery system
Well-ordered mesoporous bioactive glasses (MBG): A promising bioactive drug delivery system
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DOI：
10.1016/j.jconrel.2005.11.002
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发表时间：
2006-02-21
影响因子：
10.8
通讯作者：
Chang, J
中科院分区：
文献类型：
--
作者：
Xia, W;Chang, J
局部药物释放系统被认为是治疗骨感染的一种替代方法。本文采用两步酸催化自组装结合水热处理的方法，在水溶液中合成了具有高比表面积的有序介孔生物活性玻璃（MBG）。采用吸附法将庆大霉素包封于MBG中，并分别在蒸馏水和改良模拟体液中进行体外释放实验。结果表明，MBG的载药量是传统溶胶-凝胶58 S的3倍以上。在蒸馏水中和模拟体液中的药物释放结果表明，M58 S有效地降低了初始突释。在释放期间，庆大霉素从M58 S中的释放速率比在蒸馏水和SBF中浸泡后的58 S低得多。此外，药物释放对释放介质的pH和离子浓度敏感，这表明可能控制释放速率。此外，与传统的溶胶-凝胶58 S相比，M58 S具有更高的诱导羟基磷灰石（HAp）形成的能力。因此，有序介孔生物活性玻璃可作为生物活性药物释放体系用于骨植入材料的制备。(C)2005 Elsevier B. V.保留所有权利。
The local drug release system is considered to be an alternative to treat the bone infection. In this paper, well-ordered mesoporous bioactive glasses (MBG) with high specific surface area have been synthesized in aqueous solution by a two-step acid-catalyzed self-assembly process combined with hydrothermal treatment. Gentamicin was encapsulated into the MBG by adsorption method and in vitro release of gentamicin from MBG was performed in distilled water and modified simulated body fluid (SBF), respectively. The results showed that the amount of drug loading of MBG was three times more than that of conventional sol-gel 58S. The outcomes of drug release in distilled water and in SBF showed that M58S effectively decreased the initial burst. During the release period, gentamicin was released from the M58S at a much lower release rate as compared to that from 58S after soaking in distilled water and SBF. Furthermore, the drug release was sensitive to the pH and ionic concentration of the release medium suggesting possible controls of the release rate. In addition, in contrast to conventional sol-gel 58S, M58S had higher ability to induce hydroxyapatite (HAp) formation. Therefore, well-ordered mesoporous bioactive glasses might be used as a bioactive drug release system for preparation of bone implant materials. (C) 2005 Elsevier B.V. All rights reserved.