Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis
Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis
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DOI：
10.1007/s12350-014-9901-9
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发表时间：
2014-10-01
影响因子：
2.4
通讯作者：
Miller, Edward J.
中科院分区：
文献类型：
--
作者：
Ahmadian, Azadeh;Brogan, Ashley;Miller, Edward J.
FDG PET/CT与心肌灌注成像是评估心脏结节病（CS）的有效方法，但解释尚未标准化。我们开发了一种量化心脏FDG PET/CT的方法，并评估了其与常规解释、灌注缺陷、临床事件和免疫抑制治疗的关系。对CS进行FDG PET/CT和MPI研究（n = 38）与肿瘤适应症的阴性对照研究（n = 10）进行回顾性比较。使用标准化摄取值（suv）进行FDG体积强度（心脏代谢活动，CMA）的定量测量。CMA （477.7 +/- A 909 vs 0.55 +/- A 2.1 vs 0.3 +/- A 0.3 g葡萄糖，P = 0.02）在视觉fdg阳性研究中显著高于视觉阴性和肿瘤阴性研究。在CS患者中，EF < 50% （760.3 +/- A 1148 vs 87.4 +/- A 161 g葡萄糖，P = 0.03）和先前不良临床事件（1095 +/- A 1253 vs 73 +/- A 144 g葡萄糖，P = 0.006）的研究中CMA更大。通过多变量分析，CMA是事件的唯一独立预测因子。在重复检查的患者中（n = 7）， 6例患者中有5例的CMA在强的松治疗后降低。CS中FDG摄取的定量与较低的EFs、临床事件和免疫抑制治疗相关。
FDG PET/CT with myocardial perfusion imaging is a useful method for evaluating cardiac sarcoidosis (CS), but interpretation is not standardized. We developed a method for quantification of cardiac FDG PET/CT and evaluated its relationship to conventional interpretation, perfusion defects, clinical events, and immunosuppressive treatment.FDG PET/CT with MPI studies performed for CS (n = 38) were retrospectively compared to negative control studies acquired for oncologic indications (n = 10). Quantitative measures of FDG volume-intensity (Cardiac Metabolic Activity, CMA) was performed using standardized uptake values (SUVs). CMA (477.7 +/- A 909 vs 0.55 +/- A 2.1 vs 0.3 +/- A 0.3 g glucose, P = .02) was significantly greater in visually FDG-positive studies compared to visually negative and oncologic negative studies. Among patients with CS, CMA was greater in studies with an EF < 50% (760.3 +/- A 1,148 vs 87.4 +/- A 161 g glucose, P = .03) and preceding an adverse clinical event (1,095 +/- A 1,253 vs 73 +/- A 144 g glucose, P = .006). CMA was the only independent predictor of events by multivariate analysis. In patients with repeat examinations (n = 7), CMA decreased with prednisone treatment in 5 of 6 patients.Quantification of FDG uptake in CS correlates with lower EFs, clinical events, and immunosuppression treatment.