Engineering large animal models of human disease.
Engineering large animal models of human disease.
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DOI：
10.1002/path.4648
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Telugu BP
中科院分区：
文献类型：
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作者：
Whitelaw CB;Sheets TP;Lillico SG;Telugu BP
最近开发的用于牲畜的基因编辑工具和方法使得能够产生新的动物疾病模型。这些工具有助于基因组的位点特异性突变，允许生产携带已知人类疾病突变的动物。在这篇综述中，我们描述了各种基因编辑工具以及它们如何用于一系列大型动物疾病模型。这种基因组技术尚处于起步阶段，但预计通过使用基因编辑工具，我们将看到可用于人类疾病研究和将这些知识转化为临床的动物模型资源急剧增加。比较病理学将是这些动物模型的生产性使用和新的治疗策略的成功翻译的核心。版权所有© 2015作者.病理学杂志由John Wiley & Sons Ltd代表大不列颠和爱尔兰病理学会出版。
The recent development of gene editing tools and methodology for use in livestock enables the production of new animal disease models. These tools facilitate site‐specific mutation of the genome, allowing animals carrying known human disease mutations to be produced. In this review, we describe the various gene editing tools and how they can be used for a range of large animal models of diseases. This genomic technology is in its infancy but the expectation is that through the use of gene editing tools we will see a dramatic increase in animal model resources available for both the study of human disease and the translation of this knowledge into the clinic. Comparative pathology will be central to the productive use of these animal models and the successful translation of new therapeutic strategies. © 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.