Hepatitis B virus and cigarette smoking: risk factors for hepatocellular carcinoma in Hong Kong.
Hepatitis B virus and cigarette smoking: risk factors for hepatocellular carcinoma in Hong Kong.
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发表时间：
1982-12
期刊：
影响因子：
11.2
通讯作者：
K. Lam;MimiC. Yu;Joseph Wai-hin Leung;B. Henderson
中科院分区：
文献类型：
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作者：
K. Lam;MimiC. Yu;Joseph Wai-hin Leung;B. Henderson
对107例原发性肝细胞癌（PHC）患者和107例医院对照者的B型肝炎表面抗原、吸烟、饮酒和饮食习惯进行了比较。82%的PHC病例为B型肝炎表面抗原阳性，而对照组为18%（相对危险度，21.3; 95%置信限，10.1和45.9）。既往黄疸史与PHC显著相关，与B型肝炎表面抗原状态无关。吸烟与B型肝炎表面抗原阴性的原发性肝癌之间存在显著相关性。重度吸烟者（20支以上/天）与轻度吸烟者和非吸烟者相比，发生B型肝炎表面抗原阴性PHC的相对风险为3.3（95%置信限，1.0和13.4）。我们的数据表明，感染B型肝炎病毒和吸烟是原发性肝癌的独立危险因素。
One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative risk, 21.3; 95% confidence limits, 10.1 and 45.9). Prior history of jaundice was significantly related to PHC, independent of hepatitis B surface antigen status. There was a significant association between cigarette smoking and PHC negative for hepatitis B surface antigen. The relative risk of hepatitis B surface antigen-negative PHC for heavy smokers (20 + cigarettes/day) was 3.3 compared to light smokers and nonsmokers (95% confidence limits, 1.0 and 13.4). Our data indicated that infection by the hepatitis B virus and cigarette smoking were independent risk factors for PHC.