TH1 AND TH2 SUBSETS - PARADIGMS LOST
TH1 AND TH2 SUBSETS - PARADIGMS LOST
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DOI：
10.1016/0167-5699(95)80004-2
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发表时间：
1995-08-01
期刊：
影响因子：
--
通讯作者：
KELSO, A
中科院分区：
文献类型：
--
作者：
KELSO, A
辅助性T细胞1（Th 1）/Th 2模型为研究和解释许多免疫反应提供了一个有价值的框架，现在已经渗透到当前对T细胞调节作用的思考中。然而，单个T细胞和克隆在其细胞因子谱中显示出显著的多样性，共同形成了一个连续的谱，其中Th 1和Th 2细胞可能只是两种可能的极端表型。出于这些原因，Anne Kelso认为产生细胞因子的T细胞不能被分类为离散的子集。
The T helper 1 (Th1)/Th2 model has provided a valuable framework to investigate and explain many immune reactions and now pervades current thinking on the regulatory role of T cells. However, individual T cells and clones display remarkable diversity in their cytokine profiles, collectively forming a continuous spectrum in which Th1 and Th2 cells may be only two of-the possible extreme phenotypes. For these reasons, Anne Kelso argues that cytokine-producing T cells cannot be classified into discrete subsets.