A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
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DOI：
10.1016/j.schres.2008.02.007
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发表时间：
2008-04-01
影响因子：
4.5
通讯作者：
Pearlson, Godfrey D.
中科院分区：
文献类型：
--
作者：
Meda, Shashwath A.;Giuliani, Nicole R.;Pearlson, Godfrey D.
背景：许多研究采用基于体素的 MRI 图像形态测量 (VBM) 作为研究精神分裂症皮质灰质差异的自动化方法。然而，这些研究的结果差异很大，可能是由于不同的方法或统计方法。 目的：使用 VBM 来调查样本中精神分裂症的灰质差异，该样本显着大于迄今为止发表的任何样本，并提高统计功效，足以揭示较小分析中遗漏的差异。方法：从四个地理位置获取磁共振全脑图像，全部使用相同型号的 1.5T 扫描仪和软件版本，并将其合并形成包含 200 名首发和慢性患者的样本精神分裂症患者和 200 名健康对照者，年龄、性别和扫描仪位置相匹配。使用优化的 VBM 评估和比较灰质浓度。结果：与健康对照相比，精神分裂症患者的多个皮质和皮质下区域的灰质浓度显着降低，其中一些区域以前未报告。总体而言，我们发现先前研究中确定的区域灰质浓度较低，其中大多数仅报告了受影响区域的子集。结论：使用大量、多样化且具有代表性的样本，可以最全面地阐明精神分裂症的灰质差异。 (C) 2008 Elsevier B.V. 保留所有权利。
Background: Many studies have employed voxel-based morphometry (VBM) of MRI images as an automated method of investigating cortical gray matter differences in schizophrenia. However, results from these studies vary widely, likely due to different methodological or statistical approaches.Objective: To use VBM to investigate gray matter differences in schizophrenia in a sample significantly larger than any published to date, and to increase statistical power sufficiently to reveal differences missed in smaller analyses.Methods: Magnetic resonance whole brain images were acquired from four geographic sites, all using the same model 1.5T scanner and software version, and combined to form a sample of 200 patients with both first episode and chronic schizophrenia and 200 healthy controls, matched for age, gender and scanner location. Gray matter concentration was assessed and compared using optimized VBM.Results: Compared to healthy controls, schizophrenia patients showed significantly less gray matter concentration in multiple cortical and subcortical regions, some previously unreported. Overall, we found lower concentrations of gray matter in regions identified in prior studies, most of which reported only subsets of the affected areas.Conclusions: Gray matter differences in schizophrenia are most comprehensively elucidated using a large, diverse and representative sample. (C) 2008 Elsevier B.V. All rights reserved.