FURTHER EVIDENCE FOR THE ABSENCE OF A DESCENDING CHOLINERGIC PROJECTION FROM THE BRAIN-STEM TO THE SPINAL-CORD IN THE RAT
FURTHER EVIDENCE FOR THE ABSENCE OF A DESCENDING CHOLINERGIC PROJECTION FROM THE BRAIN-STEM TO THE SPINAL-CORD IN THE RAT
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DOI：
10.1016/0304-3940(91)90758-l
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发表时间：
1991-07-08
影响因子：
2.5
通讯作者：
MORRISON, JFB
中科院分区：
文献类型：
--
作者：
SHERRIFF, FE;HENDERSON, Z;MORRISON, JFB
已知5-羟色胺能神经元和儿茶酚胺能神经元从脑干投射到脊髓。然而，尽管免疫细胞化学和生理学证据表明胆碱能对脊髓的影响，但胆碱能的球脊髓投射的证据很少。在这项研究中，我们研究了一个直接的胆碱能球脊髓投射的可能性，在大鼠使用相结合的逆行轴突追踪技术和胆碱乙酰转移酶免疫细胞化学。虽然发现许多细胞从脑干投射到脊髓，但没有一个被鉴定为胆碱能细胞，证实了以前的证据，即脊髓的胆碱能神经支配是内在的。
Serotonergic and catecholaminergic neurons are known to project from the brainstem to the spinal cord. However, evidence for a bulbo-spinal projection that is cholinergic is sparse despite immunocytochemical and physiological evidence for a cholinergic influence on the cord. In this study we examined the possibility of a direct cholinergic bulbo-spinal projection in the rat using a combination of retrograde axonal tracing techniques and choline acetyltransferase immunocytochemistry. Although many cells were found to project to the cord from the brainstem, none were identified as being cholinergic, confirming previous evidence that the cholinergic innervation of the cord is intrinsic.