Autophagy and p53.
Autophagy and p53.
复制标题
自噬与p53。
DOI：
10.1101/cshperspect.a026120
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发表时间：
2016-04-01
影响因子：
5.4
通讯作者：
White E
中科院分区：
文献类型：
--
作者：
White E
大自噬（下文称为自噬）捕获、降解和降解细胞内组分以维持代谢稳态以及蛋白质和细胞器质量控制。因此，自噬促进饥饿中的存活并防止组织退化。自噬与p53之间存在重要关系。自噬抑制p53，p53也激活自噬。通过自噬抑制p53对于肿瘤促进是重要的，并且也可能对于防止组织变性是重要的。或者，p53对自噬的激活表明自噬是p53保护功能的一部分。揭示自噬-p53相互作用的潜在机制对人类疾病和治疗具有重要意义。
Macroautophagy (autophagy hereafter) captures, degrades, and recycles intracellular components to maintain metabolic homeostasis and protein and organelle quality control. Autophagy thereby promotes survival in starvation and prevents tissue degeneration. There is an important relationship between autophagy and p53. Autophagy suppresses p53 and also p53 activates autophagy. The suppression of p53 by autophagy is important for tumor promotion and likely also for preventing tissue degeneration. Alternatively, the activation of autophagy by p53 suggests that autophagy is part of the protective function of p53. Uncovering the underlying mechanisms of the autophagy–p53 reciprocal functional interaction and has important implications for human disease and treatment.