Time to re-evaluate the guideline value for manganese in drinking water?
Time to re-evaluate the guideline value for manganese in drinking water?
复制标题
是时候在饮用水中重新评估锰的指南价值了吗？
DOI：
10.1289/ehp.10316
复制
发表时间：
2007-11
影响因子：
10.4
通讯作者：
Vahter M
中科院分区：
文献类型：
--
作者：
Ljung K;Vahter M
我们回顾了目前基于健康的世界卫生组织（WHO）饮用水中锰的指导值的科学背景。最初的出发点是制定世卫组织饮用水中锰的指导值以及关于锰摄入量的其他法规和建议的背景文件。这些文件中提到的数据可追溯到原始研究论文。此外，我们还搜索了有关锰暴露和健康影响的科学报告。目前基于健康的饮用水中锰的指导值部分基于有争议的假设，其中使用了以前报告中的信息，而没有重新审查原始科学文章。目前，用锰浓度等于WHO指导值的水制备普通婴儿配方食品将导致超过婴儿配方食品的最大锰浓度。然而，关于这一最大值是如何得出的，还存在不确定性。同时，有越来越多的证据表明，儿童过度接触锰会产生负面的神经系统影响。越来越多的研究报告神经系统症状和锰暴露之间的关联，在婴儿和儿童，结合可疑的科学背景数据用于设置饮用水锰的指导值，当然值得重新评估的指导值。需要进一步研究以了解锰暴露与儿童健康之间的因果关系，并改进风险评估。
We reviewed the scientific background for the current health-based World Health Organization (WHO) guideline value for manganese in drinking water. The initial starting point was the background document for the development of the WHO’s guideline value for manganese in drinking water as well as other regulations and recommendations on manganese intake levels. Data referred to in these documents were traced back to the original research papers. In addition, we searched for scientific reports on manganese exposure and health effects. The current health-based guideline value for manganese in drinking water is based partly on debatable assumptions, where information from previous reports has been used without revisiting original scientific articles. Presently, preparation of common infant formulas with water containing manganese concentrations equivalent to the WHO guideline value will result in exceeding the maximum manganese concentration for infant formula. However, there are uncertainties about how this maximum value was derived. Concurrently, there is increasing evidence of negative neurologic effects in children from excessive manganese exposure. The increasing number of studies reporting associations between neurologic symptoms and manganese exposure in infants and children, in combination with the questionable scientific background data used in setting the manganese guideline value for drinking water, certainly warrant a re-evaluation of the guideline value. Further research is needed to understand the causal relationship between manganese exposure and children’s health, and to enable an improved risk assessment.
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DOI：
10.1196/annals.1306.009
发表时间：
2004-01-01
期刊：
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS
影响因子：
--
作者：
Dobson, AW;Erikson, KM;Aschner, M
通讯作者：
Aschner, M
DOI：
10.1016/s0946-672x(96)80037-x
发表时间：
1996-12-01
影响因子：
3.5
作者：
Alarcon, OM;ReinosaFuller, JA;Gamboa, J
通讯作者：
Gamboa, J
DOI：
10.1080/02652039009373885
发表时间：
1990-03-01
影响因子：
2.9
作者：
ELLEN, G;EGMOND, E;TOLSMA, K
通讯作者：
TOLSMA, K
影响因子：
3.4
作者：
Dorman, David C.;Struve, Melanie F.;Andersen, Melvin E.
通讯作者：
Andersen, Melvin E.
影响因子：
9.8
作者：
Biego, GH;Joyeux, M;Debry, G
通讯作者：
Debry, G