Functional magnetic resonance imaging of methamphetamine craving
Functional magnetic resonance imaging of methamphetamine craving
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DOI：
10.1016/j.clinimag.2012.02.006
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发表时间：
2012-11-01
期刊：
影响因子：
2.1
通讯作者：
Cai, Ze-Long
中科院分区：
文献类型：
--
作者：
Yin, Jing-Jing;Ma, Shu-Hua;Cai, Ze-Long
本研究旨在利用功能磁共振成像（fMRI）技术探讨甲基苯丙胺渴求相关脑区的异常激活，揭示成瘾的神经生物学基础。26名甲基苯丙胺成瘾者和26名健康受试者在观看快乐、悲伤或甲基苯丙胺图片时进行脑功能磁共振成像扫描，以获取资源数据。采用SPM5对fMRI数据进行分析，得到相应的脑激活图，发现甲基苯丙胺成瘾者在观看甲基苯丙胺线索图片时，扣带回激活较高，额叶激活较低。这项研究表明，甲基苯丙胺成瘾者有情绪相关的大脑激活异常。(C)2012 Elsevier Inc. All rights reserved.
The study aimed to explore the abnormal activation of special brain areas associated with methamphetamine craving using functional magnetic resonance imaging (fMRI) and to reveal the neurobiological basis of addiction. Twenty-six methamphetamine addicts and 26 healthy subjects were scanned by brain fMRI while watching pictures of happy, sad, or methamphetamine to acquire resource data. SPM5 was used to analyze fMRI data to get related brain activation map, and it was found that methamphetamine addicts had high brain activation in cingulate and low activation in frontal lobe when watching methamphetamine-cue pictures. This study demonstrated that methamphetamine addicts had emotion-related brain activation abnormalities. (C) 2012 Elsevier Inc. All rights reserved.