Impairment of several immune functions in anxious women
Impairment of several immune functions in anxious women
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DOI：
10.1016/j.jpsychores.2006.07.030
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发表时间：
2007-01-01
影响因子：
4.7
通讯作者：
De la Fuente, Monica
中科院分区：
文献类型：
--
作者：
Arranz, Lorena;Guayerbas, Noelia;De la Fuente, Monica
目的：焦虑患者免疫功能改变的研究结果存在争议。本研究的目的是研究一组焦虑妇女的免疫功能。方法：33名焦虑和33名非焦虑年龄匹配的妇女。焦虑水平由贝克焦虑量表确定。采集外周血样本，并研究了几种白细胞功能以及细胞因子释放。血浆皮质醇水平和总抗氧化能力也进行了评价。结果如下：结果表明，减少趋化作用，吞噬作用，淋巴细胞增殖反应的植物血凝素有丝分裂原，自然杀伤活性，白细胞介素-2释放，并增加超氧阴离子水平和肿瘤坏死因子-α的释放焦虑的妇女。这些受试者的血浆皮质醇增加，而总抗氧化能力降低。结论：研究结果表明，受损的免疫功能和细胞因子的释放在焦虑的妇女。这可能与皮质醇分泌增加有关，这将导致氧化应激，反映在血浆总抗氧化能力降低。(c)2007爱思唯尔公司All rights reserved.
Objective: Controversial results concerning immune function changes taking place in anxious subjects have been obtained. The aim of the present work was to study immune function in a group of anxious women. Methods: Thirty-three anxious and 33 non-anxious age-matched women were included. Anxiety levels were determined by the Beck Anxiety Inventory. Peripheral blood samples were collected, and several leukocyte functions, as well as cytokine release, were studied. Plasma cortisol levels and total antioxidant capacity were also evaluated. Results: The results showed diminished chemotaxis, phagocytosis, lymphoproliferation in response to phytohemagglutinin mitogen, natural killer activity, and interleukin-2 release, and augmented superoxide anion levels and tumor necrosis factor-alpha release in anxious women. Plasma cortisol was increased, while total antioxidant capacity was lowered in those subjects. Conclusions: The findings suggest impaired immune function and cytokine release in anxious women. This might be related to increased cortisol secretion, which would lead to oxidative stress reflected in lowered plasma total antioxidant capacity. (c) 2007 Elsevier Inc. All rights reserved.