17-BETA-ESTRADIOL AT A PHYSIOLOGICAL DOSE ACUTELY INCREASES DOPAMINE TURNOVER IN RAT-BRAIN
17-BETA-ESTRADIOL AT A PHYSIOLOGICAL DOSE ACUTELY INCREASES DOPAMINE TURNOVER IN RAT-BRAIN
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DOI：
10.1016/0014-2999(85)90604-1
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
BEDARD, P
中科院分区：
文献类型：
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作者：
DIPAOLO, T;ROUILLARD, C;BEDARD, P
卵巢切除大鼠皮下注射17β-雌二醇（30 ng，s.c.）结果表明，多巴胺代谢产物二羟苯乙酸（DOPAC）和高香草酸（HVA）增加，而纹状体和丘脑核中多巴胺浓度无变化。在类固醇注射后30分钟观察到这种增加，并且与血浆17β-雌二醇浓度峰值一致。血浆催乳素浓度在30 ng 17β-雌二醇后没有显著升高。在单侧脚内核损伤的卵巢切除大鼠中，相同剂量的17β-雌二醇诱导了损伤侧的姿势偏离，在30分钟时达到最大值。因此，非常小剂量的雌二醇能够增加多巴胺周转。这种效果在几分钟内就出现了，而且时间相对较短。它可能是非基因组的，突触前的，类似于小剂量多巴胺释放剂的作用。
Ovariectomized rats injected with 17β-estradiol (30 ng, s.c.) showed an increase of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) with no change of dopamine concentrations in the striatum and nucleus accumbens. This increase was observed 30 min after the steroid injection and coincided with peak plasma 17β-estrabiol concentrations. Plasma prolactin concentrations were not significantly elevated after 30 ng of 17β-estradiol. In ovariectomized rats with a unilateral lesion of the entopeduncular nucleus, the same dose of 17β-estradiol induced a postural deviation to the lesioned side with a maximum at 30 min. Thus, very small doses of estradiol were able to increase dopamine turnover. This effect was seen within minutes and was relatively short. It is probably non-genomic, presynaptic and similar to the effect of a small dose of a dopamine releasing agent.