Evidence for a neural basis of age-related visual field loss in normal observers.
Evidence for a neural basis of age-related visual field loss in normal observers.
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DOI：
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发表时间：
1989-09
影响因子：
4.4
通讯作者：
C. Johnson;Anthony J. Adorns;R. Lewis
中科院分区：
文献类型：
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作者：
C. Johnson;Anthony J. Adorns;R. Lewis
许多研究已经报道了在正常个体中，视野敏感度随着年龄的增加而降低。这种与年龄相关的敏感性丧失主要归因于瞳孔大小的减小和眼介质（特别是透镜）的透射损失，尽管也提出了视网膜、视神经和视觉皮层中的神经损失。我们评估了视网膜前因素对与衰老相关的正常视野变化的作用。用改良Humphrey视野分析仪的30-2程序对62名正常人（年龄20 ~ 72岁）双眼中心视野进行了测量。采用三种测试程序：（1）标准视野评估;（2）黄色背景条件下的黄色目标（530 nm截止滤光片）以使透镜传输损耗随老化的影响最小化;以及（3）大目标/高背景亮度“黄上黄”测试条件（530 nm截止滤光片，635 asb背景，尺寸V目标）以最小化瞳孔尺寸和透镜对中心视野灵敏度的影响。此外，获得每例受试者的相对透镜吸收估计值。所有三个测试条件显示，随着年龄的增长（约0.8分贝每十年）的视野灵敏度的损失，但没有发现有意义的差异，在三个测试程序。相对透镜密度随年龄增长而增加，但与三种测试条件中任何一种的视野灵敏度无关。这些数据表明，正常的年龄相关的视野敏感性变化主要是由于神经损失，而不是视网膜前因素。
Many studies have reported a decrease in visual field sensitivity as a function of increasing age in normal individuals. This age-related sensitivity loss has mainly been attributed to reductions in pupil size and transmission losses of the ocular media (particularly the lens), although neural losses in the retina, optic nerve and visual cortex have also been suggested. We evaluated the role of preretinal factors on normal visual field changes associated with aging. The central visual field of both eyes of 62 normal subjects (ages 20 to 72) were evaluated with Program 30-2 of a modified Humphrey Field Analyzer. Three test procedures were employed: (1) a standard visual field evaluation; (2) a yellow target on a yellow background condition (530 nm cutoff filter) to minimize the influence of lens transmission losses with age; and (3) a large target/high background luminance "yellow on yellow" test condition (530 nm cutoff filter, 635 asb background, Size V target) to minimize both pupil size and lens effects on central visual field sensitivity. In addition, relative lens absorption estimates were obtained for each subject. All three test conditions revealed a loss in visual field sensitivity with increasing age (approximately 0.8 dB per decade) but no meaningful differences were found among the three test procedures. Relative lens density increased with age but was not related to visual field sensitivity for any of the three test conditions. These data suggest that normal age-related visual field sensitivity changes are primarily due to neural losses rather than preretinal factors.