Simultaneous edited MRS of GABA, glutathione, and ethanol.
Simultaneous edited MRS of GABA, glutathione, and ethanol.
复制标题
同时编辑 GABA、谷胱甘肽和乙醇的 MRS。
DOI：
10.1002/nbm.4227
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发表时间：
2020
影响因子：
2.9
通讯作者：
Porges,EricC
中科院分区：
文献类型：
--
作者：
Saleh,MuhammadG;Wang,Min;Mikkelsen,Mark;Hui,SteveCN;Oeltzschner,Georg;Boissoneault,Jeff;Stennett,Bethany;Edden,RichardAE;Porges,EricC
这项工作的目的是使用 Hadamard 编码和 3T MEGA 编辑光谱 (HERMES) 重建来开发 γ-氨基丁酸 (GABA)、谷胱甘肽 (GSH) 和乙醇 (EtOH) 的同步编辑 MRS。对 HERMES 进行了密度矩阵模拟，并与体模实验进行了比较。饮酒后约 30 分钟，在六名健康志愿者身上进行了体内实验。HERMES 的模拟显示 GABA、GSH 和 EtOH 编辑的光谱具有较低的串扰水平，并且与幻影光谱高度一致。体内实验显示，在各自的 Hadamard 组合光谱中，3.0 ppm 处的 GABA 信号、2.95 ppm 处的 GSH 和 1.18 ppm 处的 EtOH 信号均经过良好编辑。测得的 GABA/Cr 积分比为 0.082 ± 0.012，GSH/Cr 为 0.037 ± 0.006，EtOH/Cr 为 0.305 ± 0.129。 HERMES 的模拟、模型和体内测量显示 GABA、GSH 和 EtOH 编辑的信号具有出色的分离性，且串扰水平可忽略不计。与顺序采集的 MEGA-PRESS 测量相比，HERMES 可以将编辑速度提高三倍，同时保持光谱质量。
The aim of this work was to develop simultaneous edited MRS of γ‐aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding and reconstruction of MEGA‐edited spectroscopy (HERMES) at 3T.Density‐matrix simulations of HERMES were carried out and compared with phantom experiments. In vivo experiments were performed in six healthy volunteers about 30 min after alcohol consumption.Simulations of HERMES showed GABA‐, GSH‐, and EtOH‐edited spectra with low levels of crosstalk and excellent agreement with phantom spectra. In vivo experiments showed well edited GABA signals at 3.0 ppm, GSH at 2.95 ppm, and EtOH at 1.18 ppm in the respective Hadamard combination spectra. Measured integral ratios were 0.082 ± 0.012 for GABA/Cr, 0.037 ± 0.006 for GSH/Cr, and 0.305 ± 0.129 for EtOH/Cr.Simulated, phantom, and in vivo measurements of HERMES show excellent separation of GABA‐, GSH‐, and EtOH‐edited signals with negligible levels of crosstalk. HERMES allows a threefold acceleration of editing while maintaining spectral quality compared with sequentially acquired MEGA‐PRESS measurements.