Multiple myeloma.
Multiple myeloma.
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DOI：
10.1182/asheducation-2004.1.237
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
J. Harousseau;J. Shaughnessy;P. Richardson
中科院分区：
文献类型：
--
作者：
J. Harousseau;J. Shaughnessy;P. Richardson
多发性骨髓瘤的特点是浆细胞异常，浆细胞是一种白细胞。这些异常细胞的繁殖失去了控制，从骨髓中大约1%的细胞增加到大多数骨髓细胞。异常细胞在骨内形成肿瘤，引起骨痛，增加骨折的风险。如果肿瘤干扰了骨骼附近的神经，就会出现手臂或腿部的麻木或无力。受影响的个体也可能经历骨组织的丢失，特别是在头骨、脊柱、肋骨和骨盆。骨质退化会导致血液中钙过量（高钙血症），从而导致恶心、食欲不振、过度口渴、疲劳、肌肉无力和神志不清。
Multiple myeloma is characterized by abnormalities in plasma cells, a type of white blood cell. These abnormal cells multiply out of control, increasing from about one percent of cells in the bone marrow to the majority of bone marrow cells. The abnormal cells form tumors within the bone, causing bone pain and an increased risk of fractures. If the tumors interfere with nerves near the bones, numbness or weakness in the arms or legs can occur. Affected individuals may also experience a loss of bone tissue, particularly in the skull, spine, ribs, and pelvis. The deterioration of bone can result in an excess of calcium in the blood (hypercalcemia), which can lead to nausea and loss of appetite, excessive thirst, fatigue, muscle weakness, and confusion.