The epigenetic impacts of social stress: how does social adversity become biologically embedded?
The epigenetic impacts of social stress: how does social adversity become biologically embedded?
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DOI：
10.2217/epi-2016-0075
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发表时间：
2016-12
期刊：
影响因子：
3.8
通讯作者：
Cunliffe VT
中科院分区：
文献类型：
--
作者：
Cunliffe VT
表观遗传机制与社会压力因素侵蚀人类和其他动物健康的过程有关。在这里，我回顾了阐明健康社会梯度背后的生物学途径的进展，特别强调行为压力如何影响与健康相关的表观基因组变异。在关于动物优势等级中的行为以及社会地位对影响健康的行为的影响的当前知识的背景下，对表观遗传变化参与嵌入与社会地位相关的慢性压力的证据进行了审查。还考虑了表观遗传机制在创伤反应中的作用以及它们参与创伤应激的生物学影响的代际传递的证据。总而言之，这些新见解对于制定改善社会健康和福祉的战略具有重要意义。
Epigenetic mechanisms are implicated in the processes through which social stressors erode health in humans and other animals. Here I review progress in elucidating the biological pathways underlying the social gradient in health, with particular emphasis on how behavioral stresses influence epigenomic variation linked to health. The evidence that epigenetic changes are involved in embedding of social status-linked chronic stress is reviewed in the context of current knowledge about behavior within animal dominance hierarchies and the impacts of social position on behaviors that affect health. The roles of epigenetic mechanisms in responses to trauma and the evidence for their involvement in intergenerational transmission of the biological impacts of traumatic stress are also considered. Taken together, the emerging insights have important implications for development of strategies to improve societal health and well-being.