Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia
Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia
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DOI：
10.3324/haematol.2010.022459
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发表时间：
2010-09-01
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影响因子：
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通讯作者：
Sinnett, Daniel
中科院分区：
文献类型：
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作者：
Healy, Jasmine;Richer, Chantal;Sinnett, Daniel
虽然儿童急性淋巴细胞白血病是最常见的儿科癌症，其病因仍然知之甚少。为了重复最近在法裔加拿大人队列中进行的2项全基因组关联研究的结果，我们证实了5个SNP [rs7073837 rs10994982（P = 3.8x10（-4））、rs10740055（P=1.6x10（-5））、rs10821936（P=1.7x10（-7））和rs7089424（P=3.6x10（-7））]。我们还证实了超二倍体B细胞急性淋巴细胞白血病的选择性效应，并报告了ARID 5 B SNP对男性急性淋巴细胞白血病风险的性别特异性效应。这项研究为更详细的分析提供了强有力的理论基础，以确定该基因座的因果变异，并更好地了解ARID 5 B对儿童急性淋巴细胞白血病易感性的整体功能贡献。
Although childhood acute lymphoblastic leukemia is the most common pediatric cancer, its etiology remains poorly understood. In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2x10(-4)), rs10994982 (P=3.8x10(-4)), rs10740055 (P=1.6x10(-5)), rs10821936 (P=1.7x10(-7)) and rs7089424 (P=3.6x10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia. We also confirmed a selective effect for B-cell acute lymphoblastic leukemia with hyperdiploidy and report a putative gender-specific effect of ARID5B SNPs on acute lymphoblastic leukemia risk in males. This study provides a strong rationale for more detailed analysis to identify the causal variants at this locus and to better understand the overall functional contribution of ARID5B to childhood acute lymphoblastic leukemia susceptibility.