Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema
Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema
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DOI：
10.1016/s0034-5687(98)00006-1
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发表时间：
1998-03-01
期刊：
影响因子：
--
通讯作者：
Honda, T
中科院分区：
文献类型：
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作者：
Kubo, K;Hanaoka, M;Honda, T
为探讨高原肺水肿（HAPE）的发病机制，我们对7例早期HAPE患者进行了支气管肺泡灌洗（BAL）和肺血流动力学研究。检测BALF中细胞计数、生化成分、促炎细胞因子（IL-1、IL-6、IL-8和肿瘤坏死因子（TNF）-α）和抗炎细胞因子（IL-1受体拮抗剂（ra）和IL-10）浓度。所有患者均显示总细胞、肺泡巨噬细胞、中性粒细胞和淋巴细胞计数增加，蛋白质、乳酸脱氢酶、IL-1 β、IL-6、IL-8、TNF-α和IL-1 ra浓度显著升高。IL-1 α和IL-10水平未升高。患者还表现出肺动脉高压，楔压正常。肺动脉压减去楔压所得的驱动压和室内空气下的Pa-O2均与BALF中IL-6和TNF-α的浓度显著相关。这些结果表明，炎症细胞因子在HAPE的早期发挥作用，并可能与肺动脉高压有关。(C)1998年由Elsevier Science B. V.出版，版权所有。
To evaluate the pathogenesis of high-altitude pulmonary edema (HAPE), we performed bronchoalveolar lavage (BAL) and pulmonary hemodynamic studies in seven patients with HAPE at its early stage. We measured cell counts, biochemical contents, and concentrations of pro-inflammatory cytokines including interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha and of anti-inflammatory cytokines including IL-1 receptor antagonist (ra) and IL-10 in the BAL fluid (BALF). All patients showed increased counts for total cells, alveolar macrophages, neutrophils and lymphocytes, and markedly elevated concentrations of proteins, lactate dehydrogenase, IL-1 beta, IL-6, IL-8, TNF-alpha and IL-1ra. The levels of IL-1 alpha and IL-10 were not increased. Patients also showed pulmonary hypertension with normal wedge pressure. Both the driving pressure obtained as pulmonary arterial pressure minus wedge pressure and the Pa-O2 under room air were significantly correlated with the concentrations of IL-6 and TNF-alpha in the BALF. These findings suggest that the inflammatory cytokines play a role at the early stage of HAPE and might be related to pulmonary hypertension. (C) 1998 Published by Elsevier Science B.V. All rights reserved.