Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside.
Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside.
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DOI：
10.1248/cpb.44.1440
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发表时间：
1996-08
影响因子：
1.7
通讯作者：
M. Yoshikawa;H. Matsuda;H. Shimoda;H. Shimada;E. Harada;Y. Naitoh;A. Miki;J. Yamahara;N. Murakami
中科院分区：
文献类型：
--
作者：
M. Yoshikawa;H. Matsuda;H. Shimoda;H. Shimada;E. Harada;Y. Naitoh;A. Miki;J. Yamahara;N. Murakami
从绣球花炮制叶中分离得到6个生物活性成分，分别为醇C、醇D、醇E、醇G 3‘-O-葡萄糖苷、(-)-绣球烯醇-4’-O-葡萄糖苷和(+)-绣球烯醇-4‘-O-葡萄糖苷。Tunbergii Makino，以及四个山奈酚和栎素低聚糖苷。根据化学和物理化学证据确定了它们的化学结构。采用Schultz-Dale反应进行体外生物测定，结果表明，冬凌草内酯C、D、E、G和(-)-绣线烯醇4‘-O-葡萄糖苷具有抗过敏活性。对大鼠肥大细胞的组胺释放和豚鼠离体气管链的组胺收缩也有抑制作用。此外，天冬醇C、D、E和G对口腔细菌具有一定的抗菌活性。
Following the characterization of thunberginols A, B, and F, six bioactive principles, thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-O-glucoside, and (+)-hydrangenol 4'-O-glucoside, were isolated from Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, together with four kaempferol and quercetin oligoglycosides. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. Thunberginols C, D, E, and G and (-)-hydrangenol 4'-O-glucoside showed antiallergic activity in the in vitro bioassay using the Schultz-Dale reaction. These components also exhibited inhibitory activities on the histamine release from rat mast cells and on the histamine-induced contraction in isolated guinea pig tracheal chain. In addition, thunberginols C, D, E, and G showed antimicrobial activities against oral bacteria.