The immunological synapse, TCR microclusters, and T cell activation.
The immunological synapse, TCR microclusters, and T cell activation.
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DOI：
10.1007/978-3-642-03858-7_5
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发表时间：
2010
影响因子：
--
通讯作者：
T. Yokosuka;T. Saito
中科院分区：
文献类型：
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作者：
T. Yokosuka;T. Saito
T 细胞激活始于抗原特异性 T 细胞和抗原呈递细胞 (APC) 之间的相互作用。这种相互作用导致免疫突触的形成，免疫突触被认为负责抗原识别和 T 细胞激活。成像分析的最新进展为 T 细胞激活提供了新的见解。 T 细胞受体 (TCR) 微簇、TCR、激酶和接头是在 T 细胞和 APC 之间的界面上抗原识别时生成的，并作为 T 细胞激活的基本信号传导单元。 CD28 介导的共刺激也被发现受到微簇形成的调节。因此，TCR和CD28微簇形成、迁移和相互作用的动态调控是T细胞介导的免疫反应启动的关键事件。对TCR微团簇的组成和特征进行综合分析，确定了其动态特征。这篇综述将概述微簇的新发现及其在 T 细胞激活中的相关概念。
T cell activation begins with the interaction between an antigen-specific T cell and an antigen-presenting cell (APC). This interaction results in the formation of the immunological synapse, which had been considered to be responsible for antigen recognition and T cell activation. Recent advances in imaging analysis have provided new insights into T cell activation. The T cell receptor (TCR) microclusters, TCRs, kinases, and adaptors are generated upon antigen recognition at the interfaces between the T cells and the APCs and serve as a fundamental signaling unit for T cell activation. CD28-mediated costimulation is also found to be regulated by the formation of microclusters. Therefore, the dynamic regulations of TCR and CD28 microcluster formation, migration, and interaction are the key events for the initiation of T cell-mediated immune responses. Comprehensive analyses of the composition and characteristics of the TCR microcluster have identified its dynamic features. This review will outline new discoveries of the microclusters and its related concept in T cell activation.