Pathogenesis of thrombosis.
Pathogenesis of thrombosis.
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DOI：
10.1182/asheducation-2009.1.255
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Furie, Bruce
中科院分区：
文献类型：
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作者：
Furie, Bruce
止血过程是一种维持封闭高压循环系统完整性的宿主防御机制。这个过程必须保持不活跃，但要尽量减少组织损伤后血液从脉管系统的外渗。鉴于止血机制的复杂性，通过活体显微镜研究活体动物中的血栓形成，重新审视了从生物化学和细胞生物学方法发展而来的范例。其中许多范例已被证明是准确的，但鉴于整个动物实验的结果，其他范例需要重新考虑。
The hemostatic process is a host defense mechanism to preserve the integrity of the closed high pressure circulatory system. This process must remain inactive but poised to minimize extravasation of blood from the vasculature following tissue injury. Given the complexity of the hemostatic mechanism, paradigms developed from biochemical and cell biological approaches have been revisited by studying thrombus formation in a live animal by intravital microscopy. Many of these paradigms have proven accurate, but others need to be reconsidered given the results of whole animal experiments.