Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome
Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome
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DOI：
10.1079/bjn2000302
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发表时间：
2001-05-01
影响因子：
3.6
通讯作者：
Refsum, H
中科院分区：
文献类型：
--
作者：
Refsum, H
增加叶酸摄入量可以降低神经管缺陷、其他畸形以及妊娠并发症的风险。越来越多的证据表明，叶酸的有益作用可能与甲硫氨酸合成酶的功能改善有关，甲硫氨酸合成酶是一种维生素B12依赖性酶，可将同型半胱氨酸转化为甲硫氨酸。在印度，大多数人坚持素食，已知缺乏维生素B12。在这样的人群中，增加叶酸摄入量可能对出生缺陷提供最低限度的保护，而维生素B12的管理应考虑。本文综述了叶酸、维生素B12和同型半胱氨酸的代谢及其相互关系。随后简要讨论了其与出生缺陷和妊娠结局有关的生物学效应的一些拟议机制。
Increased folate intake reduces the risk of neural tube defects, other malformations and also possibly, pregnancy complications. Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. In India, the majority of the population adheres to a vegetarian diet known to be deficient in vitamin B12. In such a population, increased folate intake may offer minimal protection against birth defects, whereas vitamin B12 administration should be considered. In this review, is described the metabolism of and interrelations between folate, vitamin B12 and homocysteine. This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome.