Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women
Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women
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DOI：
10.1152/japplphysiol.00651.2020
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发表时间：
2021-03-01
影响因子：
3.3
通讯作者：
Tanaka, Hirofumi
中科院分区：
文献类型：
--
作者：
Hayashi, Koichiro;Yamaguchi, Hidetaka;Tanaka, Hirofumi
绝经后中心动脉顺应性急剧下降。经常摄入大豆蛋白和有氧运动增加动脉顺应性。雌马酚是大豆苷元通过肠道微生物组的代谢产物。我们确定雌马酚产生状态是否影响有氧运动引起的颈动脉顺应性改善。43名绝经后妇女被分配到两个干预组：1）运动和运动干预（Ex+Iso，n = 27名女性）或2）运动干预（Iso; n = 16名女性）。Ex+Iso干预组的参与者完成了为期8周的有氧运动训练，所有参与者在干预期间都服用了口服维生素A补充剂。雌马酚生产状态（雌马酚生产者或非生产者）由大豆挑战后的尿雌马酚浓度确定。在Ex+Iso干预组中，雌马酚生产者的颈动脉顺应性增加（0.084 +/- 0.030 -> 0.117 +/- 0.035 mm（2）/mmHg），但在干预后非生产者中没有（0.089 +/- 0.028 -> 0.097 +/- 0.026 mm（2）/mmHg）（交互作用; P < 0.05）。雌马酚产生者颈动脉顺应性的增加幅度显著大于非雌马酚产生者（P < 0.05）。在雌马酚干预组中，无论雌马酚状态如何，干预后任何参数均无变化。这些结果表明，雌马酚的产生状态是强制性的有氧运动训练诱导改善中央动脉顺应性在绝经后women.NEW &值得注意的异黄酮摄入和有氧运动增加中央动脉顺应性。雌马酚是大豆苷元通过肠道微生物组的代谢产物，对血管功能具有有益作用。我们首次证明了有氧运动和雌马酚产生状态的相互作用在改善绝经后妇女的中央动脉顺应性方面起着重要作用。更具体地说，雌马酚产生状态是强制性的运动训练引起的改善中央动脉顺应性绝经后妇女。
Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups: 1) exercise and isoflavone (Ex+Iso, n = 27 females) or 2) isoflavone interventions (Iso; n = 16 females). Participants of the Ex+Iso intervention group completed an 8-wk aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or nonproducers) was determined from urine equol concentrations after a soy challenge. In the Ex+Iso intervention group, carotid arterial compliance increased in the equol producers (0.084 +/- 0.030 -> 0.117 +/- 0.035 mm(2)/mmHg), but not in the nonproducers (0.089 +/- 0.028 -> 0.097 +/- 0.026 mm(2)/mmHg) after the intervention (interaction effect; P < 0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (P < 0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.NEW & NOTEWORTHY Isoflavone intake and aerobic exercise increase central artery compliance. Equol, a metabolite of isoflavone daidzein by gut microbiome, has beneficial effects on vascular function. We demonstrated for the first time that the interaction of aerobic exercise and equol production status plays an essential role in improvements in central artery compliance in postmenopausal women. More specifically, the equol-producing status was obligatory to exercise training-induced improvements in central arterial compliance in postmenopausal women.