Motor proteins at the microtubule plus-end.
Motor proteins at the microtubule plus-end.
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DOI：
10.1016/j.tcb.2006.01.004
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发表时间：
2006-03
影响因子：
19
通讯作者：
Xufeng Wu;Xin Xiang;J. Hammer
中科院分区：
文献类型：
--
作者：
Xufeng Wu;Xin Xiang;J. Hammer
微管的正端在微管和肌动蛋白细胞骨架之间的相互作用中起着中心作用。最近鉴定的一个蛋白质家族聚集在正端，使人们对这种串扰是如何完成的有了更多的机制理解。这些蛋白质被称为+端跟踪蛋白，因为它们在+端生长时似乎与+端相关联，已经被证明可以调节微管动力学，并促进+端与富含肌动蛋白的皮层之间形成连接。几种运动蛋白，包括基于肌动蛋白的运动蛋白，移动到微管两端的基于微管的运动蛋白，以及解聚微管末端的微管运动蛋白，现在可以添加到正端跟踪蛋白的列表中。在这里，我们讨论了这些马达在正端的存在如何驱动几个基本的细胞过程，包括微管末端和皮层之间界面的力产生，搜索和捕获后的囊泡移位，微管分解以及向皮层传递控制肌动蛋白组装和细胞极性的信号。
The plus-end of the microtubule has a central role in the interactions that occur between the microtubule and actin cytoskeletons. The recent identification of a family of proteins that congregate at the plus-end is enabling an increased mechanistic understanding of how this cross talk is accomplished. These proteins, termed plus-end tracking proteins because they appear to associate with the plus-end as it grows, have already been shown to regulate microtubule dynamics and to facilitate the formation of connections between the plus-end and the actin-rich cortex. Several motor proteins, including an actin-based motor, microtubule-based motors that move towards either end of the microtubule and microtubule motors that depolymerize microtubule ends, can now be added to the list of plus-end tracking proteins. Here, we discuss how the presence of these motors at the plus-end seems to drive several fundamental cellular processes involving force generation at the interface between microtubule ends and the cortex, vesicle translocation following search and capture, microtubule disassembly and the delivery of signals to the cortex that govern actin assembly and cell polarity.