Erythropoietin and erythropoiesis in anemic man following androgens.
Erythropoietin and erythropoiesis in anemic man following androgens.
复制标题
雄激素后贫血男性的促红细胞生成素和红细胞生成。
DOI：
10.1182/blood.v33.4.564.564
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发表时间：
1969
期刊：
影响因子：
20.3
通讯作者：
Raymond Alexanian
中科院分区：
文献类型：
--
作者：
Raymond Alexanian
雄激素刺激动物和人类的红细胞生成已为人所知很多年。1'2 这种活性的主要机制可能是由于雄激素升高了血清和尿液水平，因此促红细胞生成素的产生增加所致。35 即使血浆促红细胞生成素含量很高（如大多数贫血症），在施用睾酮后也可能会进一步增强。#{176} 在人类中，雄激素剂量与促红细胞生成素反应之间的关系尚未阐明，贫血患者的促红细胞生成素刺激程度尚未与正常人的效果进行比较。对这些问题进行研究是为了为使用雄激素治疗骨髓衰竭引起的贫血患者确定更合理的基础。该报告将正常、性腺功能减退和贫血患者在接受不同剂量的雄激素后，促红细胞生成素的尿排泄与红细胞体积的变化相关联。结果表明，雄激素和贫血之间的协同作用进一步刺激促红细胞生成素的产生，是大剂量雄激素在一些贫血患者中产生的红细胞生成增加的原因。
T hat androgenic hormones stimulate erythropoiesis in animals and man has been known for many years.1’2 The principle mechanism for this activity probably results from an increased production of erythropoietin since both serum and urine levels are elevated by androgens.35 Even when plasma erythropoietin content is high, as in most anemias, further enhancement may occur after administration of testosterone.#{176} In man, the relationship between androgen dose and erythropoietin response has not been clarified, and the degree of erythropoietin stimulation in anemic patients has not been compared with the effect in normal man. These problems were studied in order to define a more rational basis for the use of androgens in the treatment of patients with anemia due to bone marrow failure. This report correlates the urinary excretion of erythropoietin with changes in red cell volume in normal, hypogonadal, and anemic patients after different doses of androgenic hormones. Results suggested that further stimulation of erythropoietin production by a synergistic effect between androgens and anemia accounts for the increased erythropoiesis produced in some anemic patients by large doses of androgens.