Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine
Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine
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DOI：
10.1042/cs1030633
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发表时间：
2002-12-01
期刊：
影响因子：
6
通讯作者：
Langley-Evans, SC
中科院分区：
文献类型：
--
作者：
Jackson, AA;Dunn, RL;Langley-Evans, SC
当大鼠在怀孕期间摄入低蛋白质的食物时，它们的后代会患上高血压。在低蛋白饮食中，氨基酸甘氨酸的内源性形成被认为受到限制。甘氨酸可能成为有条件必需的，因为其内源性形成的速度不足以满足代谢需要，并且可能限制胎儿的正常发育。在本研究中，五组Wistar大鼠在怀孕期间分别饲喂含18% （w/w）酪蛋白（CON）的对照饲粮、含9%酪蛋白（MLP）的低蛋白饲粮和添加3%甘氨酸（MLPG）、丙氨酸（MLPA）或尿素（MIPU）的低蛋白饲粮。幼鼠断奶后饲喂标准实验室饲料，并在4周龄时测量血压。与CON组相比，MLP、MLPA和MLPU组的血压显著升高，但MLPG组的血压与CON组差异不显著。与CON组相比，MLP、MLPA和MLPG组的体重显著降低，但MLPU组的体重与CON组没有差异。这些数据表明，妊娠期间摄入不同形式的非必需氮，对后代的生长和功能产生不同的影响。甘氨酸的可用性似乎对正常心血管发育至关重要。
When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained. Glycine may become conditionally essential, as its rate of endogenous formation is inadequate to meet metabolic needs, and may be limiting for the normal development of the fetus. In the present study, five groups of Wistar rats were provided during pregnancy with one of five diets: a control diet containing 18% (w/w) casein (CON), a low-protein diet containing 9% casein (MLP), or the low-protein diet supplemented with 3% glycine (MLPG), alanine (MLPA) or urea (MIPU). The offspring were weaned on to standard laboratory chow, and blood pressure was measured at 4 weeks of age. Blood pressure was significantly increased in the MLP, MLPA and MLPU groups compared with the CON group, but for the MLPG group blood pressure was not significantly different from CON. Compared with the CON group, body weight was significantly reduced for the MLP, MLPA and MLPG groups, but for the MLPU group body weight was not different from CON. These data show that different forms of non-essential dietary nitrogen, when consumed during pregnancy, exert different effects upon the growth and function of the offspring. The availability of glycine appears to be of critical importance for normal cardiovascular development.