CORTICOTROPIN-RELEASING HORMONE INDUCES AN EXAGGERATED RESPONSE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN POLYCYSTIC-OVARY-SYNDROME
CORTICOTROPIN-RELEASING HORMONE INDUCES AN EXAGGERATED RESPONSE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN POLYCYSTIC-OVARY-SYNDROME
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DOI：
10.1016/s0015-0282(16)57596-7
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发表时间：
1995-06-01
影响因子：
6.7
通讯作者：
MANCUSO, S
中科院分区：
文献类型：
--
作者：
LANZONE, A;PETRAGLIA, F;MANCUSO, S
目的：评价多囊卵巢综合征(PCOS)患者对促肾上腺皮质激素释放激素(CRH)刺激的反应。设计：临床对照研究。15例年龄和体重匹配的排卵患者作为对照。干预：在卵泡早期或孕激素诱导月经后，上午8：00注射人促肾上腺皮质激素释放激素，分别在刺激后0、15、30、60、90分钟采集血样。结果：PCOS患者和对照组的基础ACTH和皮质醇水平相似。与对照组相比，PCOS患者的促肾上腺皮质激素和皮质醇对CRH的反应明显增强。此外，与对照组相比，高雄激素组ACTH和皮质醇刺激的分泌在整个研究期间都延长了，刺激60min后达到基线水平。结论：我们的结果与PCOS女性可能表现出下丘脑-垂体-肾上腺轴功能亢进的假设一致，这可能参与了导致综合征复杂性的生理病理事件。
Objective: To evaluate pituitary-adrenal responsive to corticotropin-releasing hormone (CRH) stimulus in polycystic ovary syndrome (PCOS).Design: Controlled clinical study.Patients: Twelve women aged 17 to 32 years, who had been diagnosed as having PCOS, were studied. Fifteen appropriately age- and weight-matched ovulatory patients served as the control.Intervention: In the early follicular phase or after progestin-induced menses, human CRH was injected at 8:00 A.M. and blood samples were collected at 0, 15, 30, 60, and 90 minutes after stimulus. Plasma levels of ACTH and cortisol were measured.Results: Baseline levels of ACTH and cortisol were similar in PCOS and control patients. Both ACTH and cortisol response to CRH were markedly greater in the PCOS population as compared with controls. Moreover, ACTH- and cortisol-stimulated secretion was prolonged for the whole period of the study in hyperandrogenic patients with respect to controls, where baseline levels were attained 60 minutes after the stimulus.Conclusions: Our results are consistent with the hypothesis that women with PCOS may demonstrate hyperfunction of the hypothalamic-pituitary-adrenal axis, which may be involved in the physiopathologic events leading to the complexity of the syndrome.