Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer
Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer
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DOI：
10.4103/0973-1482.165865
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发表时间：
2018-01-01
影响因子：
1.3
通讯作者：
Zhang, Yan-Lin
中科院分区：
文献类型：
--
作者：
Ji, Zhi-Yong;Li, Hai-Feng;Zhang, Yan-Lin
工作背景：本研究旨在通过Meta分析探讨磷酸酶和张力蛋白同源物（phosphatase and tensin homolog，PTEN）蛋白阳性率与非小细胞肺癌（nonsmall cell lung cancer，NSCLC）患者淋巴结转移（lymph node metastasis，LNM）和肿瘤淋巴结转移（tumor node metastasis，TNM）分期的相关性。涵盖多个电子数据库（Embase，科克伦图书馆，中国生物医学，中国国家知识基础设施，PubMed和Web of Science），符合纳入当前荟萃分析的已发表论文必须满足我们预定的选择标准。利用综合荟萃分析2.0软件（Biostatic Inc.，结果：共有12项队列研究（共419例NSCLC患者）纳入本荟萃分析。TNM分期Ⅲ ~ Ⅳ期患者的PTEN蛋白阳性率较Ⅰ ~ Ⅱ期患者低（OR = 0.454，95%CI = 0.338-0.610，P < 0.001）。无淋巴结转移的非小细胞肺癌组织中PTEN的表达高于有淋巴结转移的非小细胞肺癌组织（OR = 0.532，95%CI：0.299-0.948，P = 0.032）。种族分层分析显示，亚裔和白人中PTEN蛋白阳性率与NSCLC的TNM分期呈负相关（均P < 0.05）。结论：PTEN蛋白阳性率的降低可能与NSCLC的TNM分期和淋巴结转移有关，可能是NSCLC诊断的重要生物学指标。
Background: This study aims to investigate the correlations of positive rate of phosphatase and tensin homolog (PTEN) protein with lymph node metastasis (LNM) and tumor node metastasis (TNM) staging of nonsmall cell lung cancer (NSCLC) patients by conducted a meta-analysis.Materials and Methods: Covering several electronic databases (Embase, Cochrane Library, China BioMedicine, China National Knowledge Infrastructure, PubMed, and Web of Science), published papers eligible for enrollment in the current meta-analysis had to fulfill our predefined selection criteria. Odds ratios (ORs) with their 95% confidence interval (95%CI) were aggregated utilizing comprehensive meta-analysis 2.0 software (Biostatic Inc., Englewood, New Jersey, USA).Results: Twelve cohort studies with a total of 419 NSCLC patients were incorporated into the current meta-analysis. A decreased positive rate of PTEN protein was detected in NSCLC patients with TNM stage III-IV rather than those patients with TNM stage I-II (OR = 0.454, 95%CI = 0.338-0.610, P < 0.001). PTEN in NSCLC patients without LNM expressed higher than that in the patients with LNM (OR = 0.532, 95%CI: 0.299-0.948, P = 0.032). Ethnicity-stratified analysis demonstrated a negative relationship between positive rate of PTEN protein and TNM staging of NSCLC among both Asians and Caucasians (both P < 0.05). However, we found no significant association between positive rate of PTEN protein and LNM among Asians and Caucasians (both P > 0.05).Conclusion: Our findings indicate that decreased positive rate of PTEN protein may be linked to TNM staging and LNM in NSCLC, and it could be an important diagnostic biomarker of NSCLC.