THE IMPACT OF RECENT STEREOLOGICAL ADVANCES ON QUANTITATIVE STUDIES OF THE NERVOUS-SYSTEM
THE IMPACT OF RECENT STEREOLOGICAL ADVANCES ON QUANTITATIVE STUDIES OF THE NERVOUS-SYSTEM
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DOI：
10.1016/0165-0270(86)90112-3
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发表时间：
1986-10-01
影响因子：
3
通讯作者：
GUNDERSEN, HJG
中科院分区：
文献类型：
--
作者：
BRAENDGAARD, H;GUNDERSEN, HJG
一些新的体视学原理无偏估计的颗粒数量和尺寸和采样的颗粒的有用性一起说明了一个新的原则，无偏估计的各向异性表面。这些例子包括神经元和突触的数量和大小，突触梯度，神经元在三维空间中的点模式，毛细血管表面积和胞体体积的估计的描述。该方法的一个主要优点是可以在大脑的指定的、特征良好的区域或层中执行估计过程。简要讨论了一些一般的统计和体视学问题。
The usefulness of a number of new stereological principles for unbiased estimation of particle number and sizes and sampling of particles is illustrated together with a novel principle for unbiased estimation of anisotropic surfaces. The examples include descriptions of estimators of neurone and synapse number and sizes, synapse gradients, neurone point patterns in three-dimensional space, capillary surface area, and perikarya volumes. A major advantage of the methods is the possibility to carry out the estimation procedures in specified, well-characterized regions or layers of the brain. Some general statistical and stereological problems are briefly discussed.