For Placebo Effects in Medicine, Seeing Is Believing
For Placebo Effects in Medicine, Seeing Is Believing
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DOI：
10.1126/scitranslmed.3002120
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发表时间：
2011-02-16
影响因子：
17.1
通讯作者：
Kong, Jian
中科院分区：
文献类型：
--
作者：
Gollub, Randy L.;Kong, Jian
确定生物医学疗法疗效的金标准是在随机对照试验中检测活性药剂或程序与匹配的惰性安慰剂的疗效之间的显著差异。对于医学来说，检测这种差异已经成为一项挑战，特别是对于基于患者自我评估量表的结果。然而，导致安慰剂反应的因素几乎没有受到关注。在本期《科学转化医学》中，Bingel等人。报告一个非侵入性全脑成像如何有助于我们理解基于大脑的安慰剂效应的例子。在这里，我们重点介绍了神经成像正在催化社会对安慰剂效应的看法的革命，通过提供令人信服的可视化，反映一个人的想法、感觉和过去的经验的大脑活动如何增强或对抗他或她对治疗的反应。
The gold standard for determining the efficacy of biomedical therapies is the detection of a significant difference between the therapeutic effects of an active pharmacological agent or procedure and a matched inert placebo in a randomized controlled trial. Detecting this difference has become a challenge for medicine, especially for outcomes that are based on patient self-rated scales. Yet factors that contribute to placebo responses have received scant attention. In this issue of Science Translational Medicine, Bingel et al. report on an example of how noninvasive whole-brain imaging contributes to our understanding of brain-based placebo effects. Here we highlight ways in which neuroimaging is catalyzing a revolution in society's perspective of placebo effects by providing a compelling visualization of how brain activities that reflect a person's thoughts, feelings, and past experiences can enhance or antagonize his or her response to a medical treatment.