Letter by Knight et al regarding article, "Validation of in vivo magnetic resonance imaging blood-brain barrier permeability measurements by comparison with gold standard histology".
Letter by Knight et al regarding article, "Validation of in vivo magnetic resonance imaging blood-brain barrier permeability measurements by comparison with gold standard histology".
复制标题
Knight 等人关于文章“通过与金标准组织学比较验证体内磁共振成像血脑屏障渗透性测量”的信函。
DOI：
10.1161/strokeaha.111.633636
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发表时间：
2011
期刊：
影响因子：
8.3
通讯作者：
Ewing,JamesR
中科院分区：
文献类型：
--
作者：
Knight,RobertA;Nagaraja,TavarekereN;Ewing,JamesR
我们饶有兴趣地阅读了 Hoffmann 等人最近发表的关于血脑屏障 (BBB) 渗透性的磁共振成像 (MRI) 测量验证的论文。作者报告说，他们使用 MRI 方法结合基于 Gd 的 MRI 造影剂测量了局灶性脑缺血啮齿动物模型中血脑屏障通透性的变化；然后，他们通过将这些措施与甲酚紫组织学和伊文思蓝外渗进行比较来验证这些措施。基于 MRI 的血管渗漏估计是使用 Patlak 图解法计算血脑转移常数 (Ki) 来获得的。近年来，人们对开发能够准确测量中风后急性血脑屏障通透性变化以预测出血性转化概率的非侵入性成像技术产生了极大的兴趣。然而，作者似乎没有意识到该领域有大量工作使用 MRI 进行此类研究；他们仅引用使用计算机断层扫描技术结合 Patlak 图方法来估计 BBB 渗透性的手稿。我们想提请作者注意几项此类研究，至少其中一些值得在其出版物中引用。
We read with great interest the recent paper by Hoffmann et al1 on the validation of magnetic resonance imaging (MRI) measurements of blood-brain barrier (BBB) permeability. The authors reported that they measured changes in BBB permeability in rodent models of focal cerebral ischemia using MRI methods in conjunction with a Gd-based MRI contrast agent; they then validated these measures by comparing them with Cresyl violet histology and Evans Blue extravasation. The MRI-based estimates of vascular leakage were obtained using the Patlak graphical method to calculate the blood-to-brain transfer constant (Ki).In recent years, there has been a great deal of interest in the development of noninvasive imaging techniques capable of accurately measuring changes in acute BBB permeability after stroke to predict probability of hemorrhagic transformation. However, the authors appear to be unaware of a sizable body of work in this field that used MRI for such investigations; they only cite manuscripts that used computed tomography techniques in conjunction with Patlak plot methodology to estimate BBB permeability. We would like to bring to the authors’ attention several such studies, at least some of which deserved citations in their publication.