Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength
Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength
复制标题
DOI：
10.1016/j.bone.2019.03.033
复制
发表时间：
2019-06-01
期刊：
影响因子：
4.1
通讯作者：
Lowe, Dawn A.
中科院分区：
文献类型：
--
作者：
Collins, Brittany C.;Laakkonen, Eija K.;Lowe, Dawn A.
骨骼肌无力随着年龄的增长而发生，在女性中，这是由于雌激素的丧失和卵巢功能衰竭而加剧的。雌激素缺乏介导骨骼肌质量保存不足和剩余骨骼肌质量下降导致的肌肉力量下降。受雌激素影响的骨骼肌的过程和组成部分开始被确定。这篇评论的重点是机制，有助于损失的肌肉力量的产生时，雌激素是低的女性，相反，雌激素的强度维护。越来越多的证据表明，雌激素缺乏会诱导骨骼肌细胞凋亡，从而导致肌肉质量和力量的损失。影响质量的雌激素敏感过程，即，肌肉的力量产生能力，包括肌球蛋白磷酸化和卫星细胞功能。进一步详细说明这些机制，并确定额外的机制，雌激素对骨骼肌的影响是重要的基础设计的治疗策略，以尽量减少骨骼肌病理，如肌肉减少症和肌无力。
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle strength from both inadequate preservation of skeletal muscle mass and decrements in the quality of the remaining skeletal muscle. Processes and components of skeletal muscle that are affected by estrogens are beginning to be identified. This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen. Evidence is accumulating that estrogen deficiency induces apoptosis in skeletal muscle contributing to loss of mass and thus strength. Estrogen sensitive processes that affect quality, i.e., force generating capacity of muscle, include myosin phosphorylation and satellite cell function. Further detailing these mechanisms and identifying additional mechanisms that underlie estrogenic effects on skeletal muscle is important foundation for the design of therapeutic strategies to minimize skeletal muscle pathologies, such as sarcopenia and dynapenia.