Specifying the role of the left prefrontal cortex in word selection.
Specifying the role of the left prefrontal cortex in word selection.
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DOI：
10.1016/j.bandl.2015.07.007
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发表时间：
2015-10
影响因子：
2.5
通讯作者：
Dronkers NF
中科院分区：
文献类型：
--
作者：
Riès SK;Karzmark CR;Navarrete E;Knight RT;Dronkers NF
Word selection allows us to choose words during language production. This is often viewed as a competitive process wherein a lexical representation is retrieved among semantically-related alternatives. The left prefrontal cortex (LPFC) is thought to help overcome competition for word selection through top-down control. However, whether the LPFC is always necessary for word selection remains unclear. We tested 6 LPFC-injured patients and controls in two picture naming paradigms varying in terms of item repetition. Both paradigms elicited the expected semantic interference effects (SIE), reflecting interference caused by semantically-related representations in word selection. However, LPFC patients as a group showed a larger SIE than controls only in the paradigm involving item repetition. We argue that item repetition increases interference caused by semantically-related alternatives, resulting in increased LPFC-dependent cognitive control demands. The remaining network of brain regions associated with word selection appears to be sufficient when items are not repeated.
