Interaction of waist/hip ratio and family history on the risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women
Interaction of waist/hip ratio and family history on the risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal women
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DOI：
10.1093/aje/155.3.225
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发表时间：
2002-02-01
影响因子：
5
通讯作者：
Folsom, AR
中科院分区：
文献类型：
--
作者：
Sellers, TA;Davis, J;Folsom, AR
作者先前在爱荷华州妇女健康研究中报道了腰臀比和家族史对乳腺癌风险的相互作用。在这里，他们根据额外9年的随访，对雌激素和孕激素的肿瘤受体进行了分层，重新研究了这种关联。1986年确定了有关乳腺癌危险因素和家族史的数据。通过爱荷华州监测、流行病学和最终结果登记处确定乳腺癌和雌激素受体/孕激素受体的发生率。在18岁时，比率随体重和体重指数的增加而升高，随体重指数的降低而升高，但家族史并不影响比率。与身高、腰围或腰臀比无关。在家族史阳性的女性中观察到风险随腰/臀比增加而增加的线性趋势（p = 0.06），但在家族史阴性的女性中没有观察到（p = 0.87）。通过雌激素受体或孕激素受体状态检查这种明显的相互作用（p = 0.09）。当按家族史和雌激素受体分层时，没有明显的模式。相比之下，在腰/臀比值较高的五分位数中，家族史阳性的女性发生孕酮受体阴性肿瘤的风险是最低五分位数的2.2倍（95%置信区间：0.9，5.8）。因此，以前报道的家族史和腰/臀比之间的相互作用仍然（弱）明显，似乎反映了孕激素受体阴性肿瘤的风险。
The authors previously reported an interaction of waist/hip ratio and family history on the risk of breast cancer in the Iowa Women's Health Study. Here they reexamine this association based on 9 additional years of follow-up, stratifying on tumor receptors for estrogen and progesterone. Data on risk factors and family history of breast cancer were ascertained in 1986. The occurrences of breast cancer and estrogen receptor/progesterone receptor were determined through the Iowa Surveillance, Epidemiology, and End Results' registry. Rate ratios were elevated with increasing weight and body mass index and decreasing body mass index at age 18 years, but they did not vary by family history. There was no association with height, waist circumference, or waist/hip ratio. A linear trend of increasing risk with increasing waist/hip ratio was observed among family history-positive women (p = 0.06) but not among family history-negative women (p = 0.87). This apparent interaction (p = 0.09) was examined by estrogen receptor or progesterone receptor status. When stratified on family history and estrogen receptor, no clear patterns were evident. In contrast, family history-positive women in the upper quintile of the waist/hip ratio were at 2.2-fold greater risk of progesterone receptor-negative tumors compared with those in the lowest quintile (95% confidence interval: 0.9, 5.8). Thus, the previously reported interaction between family history and waist/hip ratio is still (weakly) evident and appears to reflect risk for progesterone receptor-negative tumors.