Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer.
Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer.
复制标题
DOI：
10.3332/ecancer.2015.525
复制
发表时间：
2015
影响因子：
1.8
通讯作者：
Das B
中科院分区：
文献类型：
--
作者：
Mishra A;Kumar R;Tyagi A;Kohaar I;Hedau S;Bharti AC;Sarker S;Dey D;Saluja D;Das B
在这项研究中，我们研究了天然抗氧化剂姜黄素对HPV16阳性口腔癌细胞系93VU147T的影响，并证明姜黄素不仅是宿主核转录因子AP-1和NF-kB活性的有效抑制剂，而且在口腔癌细胞的致癌过程中选择性抑制HPV16/E6癌基因的转录。这项研究表明姜黄素对高危人乳头瘤病毒 (HPV) 感染的口腔癌具有治疗潜力。
In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.