Twenty-year review of radiotherapy for vaginal cancer: An institutional experience
Twenty-year review of radiotherapy for vaginal cancer: An institutional experience
复制标题
DOI：
10.1016/j.ygyno.2008.07.007
复制
发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Pearcey, Robert
中科院分区：
文献类型：
--
作者：
Lian, Jidong;Dundas, George;Pearcey, Robert
Objective.评价阴道癌放射治疗的临床结果、预后因素和慢性发病率。材料和方法。选择68例经根治性或辅助性放疗的阴道癌患者。本研究排除了5例罕见组织病理学亚型和8例腺癌。其余76.4%患有早期疾病（1期：14，11期：28，111期：9，IV期：4）。在接受治疗的年份，患者几乎均匀分布（前5年：13例，第2年：14例，第3年：16例，第4年：12例）。治疗组分为单纯外照射放疗（EBRT）组（18例）、单纯近距离放疗（BT）组（4例）、EBRT + BT组（30例）和手术+RT组（3例）。中位随访时间为50.3个月，范围为3至213个月。5-年总生存率（OS）为55.6%，特异性生存率（DSS）为77.3%，非特异性生存率为74.2%，局部控制率为87.7%。DSS和OS的独立预后因素为肿瘤分期、部位和大小（p
Objective. To evaluate clinical outcome, prognostic factors and chronic morbidity with radiotherapy for vaginal cancer treatment.Materials and methods. 68 patient with vaginal cancer treated by radical or adjuvant radiotherapy (RT) were selected. Five with rare subtypes of histopathology and 8 with adenocarcinoma were excluded from this study. 76.4% of the remainder had early-stage diseases (stage 1: 14, 11: 28, 111: 9, and IV: 4). The patients in the years from which they were treated were almost evenly distributed (1st 5 years: 13, 2nd: 14, 3rd: 16, and 4th: 12). There were four treatment groups: external beam radiotherapy (EBRT) alone (n = 18), brachytherapy (BT) alone (n =4), EBRT and BT (n = 30), and surgery plus RT (n = 3).Results. Median follow-up was 50.3 months ranging from 3 to 213 months. 5-year overall survival (OS) was 55.6%, disease-specific survival (DSS) was 77.3%, disease-feee survival was 74.2%, and local control was 87.7%. Independent prognostic factors for DSS and OS were tumor stage, site and size (p