Instrumentation in Diffuse Optical Imaging.
Instrumentation in Diffuse Optical Imaging.
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DOI：
10.3390/photonics1010009
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发表时间：
2014-03-20
期刊：
影响因子：
2.4
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Zhang X
漫反射光学成像具有很强的通用性，在生物学和医学中有着非常广泛的应用。它涵盖了漫反射光学层析成像、荧光漫射光学层析成像、生物发光和许多其他新的成像方法。这些漫反射光学成像方法具有不同的仪器配置，但共享相同的核心物理原理-光在高扩散介质中的传播，即生物组织。本文从系统结构、光源、光检测、光谱分离、信号调制以及成像对比度等方面综述了漫反射光学成像仪器和方法的最新进展。
Diffuse optical imaging is highly versatile and has a very broad range of applications in biology and medicine. It covers diffuse optical tomography, fluorescence diffuse optical tomography, bioluminescence, and a number of other new imaging methods. These methods of diffuse optical imaging have diversified instrument configurations but share the same core physical principle – light propagation in highly diffusive media, i.e., the biological tissue. In this review, the author summarizes the latest development in instrumentation and methodology available to diffuse optical imaging in terms of system architecture, light source, photo-detection, spectral separation, signal modulation, and lastly imaging contrast.