TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome.
TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome.
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DOI：
10.3389/fnins.2016.00384
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发表时间：
2016
影响因子：
4.3
通讯作者：
Paschou P
中科院分区：
文献类型：
--
作者：
Forde NJ;Kanaan AS;Widomska J;Padmanabhuni SS;Nespoli E;Alexander J;Rodriguez Arranz JI;Fan S;Houssari R;Nawaz MS;Rizzo F;Pagliaroli L;Zilhäo NR;Aranyi T;Barta C;Boeckers TM;Boomsma DI;Buisman WR;Buitelaar JK;Cath D;Dietrich A;Driessen N;Drineas P;Dunlap M;Gerasch S;Glennon J;Hengerer B;van den Heuvel OA;Jespersgaard C;Möller HE;Müller-Vahl KR;Openneer TJ;Poelmans G;Pouwels PJ;Scharf JM;Stefansson H;Tümer Z;Veltman DJ;van der Werf YD;Hoekstra PJ;Ludolph A;Paschou P
抽动症(GTS)的特点是存在多种运动和语音的波动过程的强度，频率和严重程度。高达90%的GTS患者存在共病，最常见的是注意力缺陷/多动障碍(ADHD)和强迫症(OCD)，从而为探索跨疾病的共同病因提供了一个极好的模型。TS-EUROTRAIN(FP7-People-2012-ITN，Grant农业编号316978)是玛丽·居里初始培训网络(http://ts-eurotrain.eu))，旨在阐明GTS的发病和临床病程的复杂病因，调查GTS和相关疾病的神经生物学基础，将研究成果转化为临床应用，并为GTS的研究建立泛欧洲基础设施。这包括以下挑战：(I)收集大型遗传数据库，用于评估具有高统计能力的遗传结构；(Ii)探索基因-环境相互作用的作用，包括表观遗传现象的影响；(Iii)使用基于内表型的方法来理解GTS、强迫症和ADHD之间的共同病因；(Iv)建立GTS的发育动物模型；(V)通过横断面和纵向神经成像研究，对GTS的神经生物学机制有新的见解；以及(Vi)参与外联活动，包括向公众传播关于GTS的科学知识。来自学术界和工业界的15名合作伙伴和12名博士生参与了该项目。在这里，我们旨在分享一个跨学科项目的设计，展示GTS领域大规模合作努力的潜力。我们的最终目标是阐明GTS的复杂病因和神经生物学基础，将研究成果转化为临床应用，并为GTS和相关疾病的研究建立泛欧洲基础设施。
Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.