Risk of Mortality in Elderly Coronavirus Disease 2019 Patients With Mental Health Disorders: A Nationwide Retrospective Study in South Korea.
Risk of Mortality in Elderly Coronavirus Disease 2019 Patients With Mental Health Disorders: A Nationwide Retrospective Study in South Korea.
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DOI：
10.1016/j.jagp.2020.09.016
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Son SJ
中科院分区：
文献类型：
--
作者：
Lee DY;Cho J;You SC;Park RW;Kim CS;Lee EY;Aizenstein H;Andreescu C;Karim H;Hong CH;Rho HW;Park B;Son SJ
这项研究报告了老年精神障碍患者因冠状病毒病2019年(新冠肺炎)而导致的死亡风险。比较两组患者的特点：有无精神障碍患者提示精神障碍组有更多的新冠肺炎危险因素。这项研究表明，患有并存疾病的老年患者和服用精神药物的患者患新冠肺炎的风险可能更高。这项研究旨在调查韩国患有和不伴有精神障碍的老年冠状病毒病2019(新冠肺炎)患者的不同临床特征，并确定这些特征是否与导致死亡的潜在精神障碍有关。利用国家索赔数据库进行了一项以人口为基础的比较队列研究。对2020年1月1日至2020年4月10日期间确诊为新冠肺炎的65岁≥患者进行了评估。评估所有参与者死亡率的终点是确诊后21天或2020年4月10日的死亡。使用COX风险回归估计与精神障碍相关的死亡风险。我们确定了814名老年新冠肺炎患者(255例(31.3%)患有精神障碍，559例(68.7%)患有非精神障碍)。有精神障碍的人比没有精神障碍的人更有可能年龄更大，服用抗血栓药物，并有糖尿病、高血压、慢性阻塞性肺疾病和尿路感染。在倾向评分分层后，我们的研究包括每组781名患者(236例(30.2%)精神障碍患者和545例(69.8%)非精神障碍患者)。精神障碍组的死亡率高于非精神障碍组(12.7%[30/236]比6.8%[37/545])。然而，与非精神障碍患者相比，合并精神障碍的老年新冠肺炎患者死亡的危险比(HR：1.57，95%CI：0.95-2.56)没有统计学意义。尽管老年人精神障碍与新冠肺炎死亡率之间的关联尚不清楚，但这项研究表明，患有新冠肺炎疾病的老年患者和那些正在服用精神药物的患者患新冠肺炎的风险可能更高。
This study reports the mortality risk due to coronavirus disease 2019 (COVID-19) in elderly patients with mental disorders. Comparing characteristics between two groups: patients with and without mental disorders suggested that the mental disorder group had more risk factors for COVID-19. This study suggests that elderly patients with comorbid conditions and those taking psychiatric medications might be at a higher risk of COVID-19. This study aimed to investigate the different clinical characteristics among elderly coronavirus disease 2019 (COVID-19) patients with and without mental disorders in South Korea and determine if these characteristics have an association with underlying mental disorders causing mortality. A population-based comparative cohort study was conducted using the national claims database. Individuals aged ≥65 years with confirmed COVID-19 between January 1, 2020 and April 10, 2020 were assessed. The endpoints for evaluating mortality for all participants were death, 21 days after diagnosis, or April 10, 2020. The risk of mortality associated with mental disorders was estimated using Cox hazards regression. We identified 814 elderly COVID-19 patients (255 [31.3%] with mental disorder and 559 [68.7%] with nonmental disorder). Individuals with mental disorders were found more likely to be older, taking antithrombotic agents, and had diabetes, hypertension, chronic obstructive lung disease, and urinary tract infections than those without mental disorders. After propensity score stratification, our study included 781 patients in each group (236 [30.2%] with mental disorder and 545 [69.8%] with nonmental disorder). The mental disorder group showed higher mortality rates than the nonmental disorder group (12.7% [30/236] versus 6.8% [37/545]). However, compared to patients without mental disorders, the hazard ratio (HR) for mortality in elderly COVID-19 patients with mental disorders was not statistically significant (HR: 1.57, 95%CI: 0.95–2.56). Although the association between mental disorders in elderly individuals and mortality in COVID-19 is unclear, this study suggests that elderly patients with comorbid conditions and those taking psychiatric medications might be at a higher risk of COVID-19.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.1027/0227-5910/a000015
发表时间：
2010-01-01
影响因子：
3
作者：
Yip, Paul S. F.;Cheung, Y. T.;Law, Y. W.
通讯作者：
Law, Y. W.
影响因子：
28.2
作者：
Yang, Wenjie;Cao, Qiqi;Yan, Fuhua
通讯作者：
Yan, Fuhua
影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
影响因子：
168.9
作者：
Zhou, Fei;Yu, Ting;Cao, Bin
通讯作者：
Cao, Bin