Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations
Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations
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DOI：
10.1016/j.neuron.2006.10.023
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发表时间：
2006-12-07
期刊：
影响因子：
16.2
通讯作者：
Buzsaki, Gyoergy
中科院分区：
文献类型：
--
作者：
Isomura, Yoshikazu;Sirota, Anton;Buzsaki, Gyoergy
大脑系统通过神经元振荡在多个时间和空间尺度上进行通信。在麻醉大鼠中，我们发现，新皮层的“慢”振荡从事前额叶，躯体感觉，内嗅，和下丘脑皮质的神经元到同步的向上和向下状态之间的转换，与相应的双峰分布的膜电位。海马颗粒细胞、CA 3和CA 1锥体细胞膜电位缺乏双峰性，但受慢振荡的影响具有区域特异性。此外，在麻醉和自然睡眠的大鼠中，皮质UP状态导致齿状回和大多数CA 1神经元的活动增加，以及涟漪事件的最高概率。然而，CA 3-CA 1网络可以在DOWN状态下自组织成伽马脉冲和偶尔的波纹。因此，neo/paleocortical和海马网络定期重置，自组织，并通过缓慢的振荡时间协调他们的细胞组件。
Brain systems communicate by means of neuronal oscillations at multiple temporal and spatial scales. In anesthetized rats, we find that neocortical "slow" oscillation engages neurons in prefrontal, somatosensory, entorhinal, and subicular cortices into synchronous transitions between UP and DOWN states, with a corresponding bimodal distribution of their membrane potential. The membrane potential of hippocampal granule cells and CA3 and CA1 pyramidal cells lacked bimodality, yet it was influenced by the slow oscillation in a region-specific manner. Furthermore, in both anesthetized and naturally sleeping rats, the cortical UP states resulted in increased activity of dentate and most CA1 neurons, as well as the highest probability of ripple events. Yet, the CA3-CA1 network could self-organize into gamma bursts and occasional ripples during the DOWN state. Thus, neo/paleocortical and hippocampal networks periodically reset, self-organize, and temporally coordinate their cell assemblies via the slow oscillation.