Conditioned ethanol aversion in rats induced by voluntary wheel running, forced swimming, and electric shock: An implication for aversion therapy of alcoholism
Conditioned ethanol aversion in rats induced by voluntary wheel running, forced swimming, and electric shock: An implication for aversion therapy of alcoholism
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DOI：
10.1007/bf02734275
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发表时间：
2004-04
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影响因子：
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通讯作者：
S. Nakajima
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文献类型：
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作者：
S. Nakajima
本研究旨在证明大鼠在自愿跑步、强迫游泳或电击前对乙醇溶液产生厌恶。将缺水Wistar大鼠分为4组，每组8只大鼠，给予5%乙醇溶液灌胃15 min。饮乙醇后，立即将Run组大鼠放入单个跑步轮中15 min， Swim组大鼠放入单个游泳池15 min， Shock组大鼠在单个小室中电击15 min(15次0.45 ma，每次0.7s，每次间隔1 min)， Control组大鼠直接返回原笼。这一过程重复了六天，随后是为期两天的乙醇厌恶选择测试，其中一瓶含有5%乙醇溶液和一瓶自来水同时呈现15分钟。在测试中，跑步组、游泳组和休克组喝的乙醇溶液明显少于自来水，而对照组喝的两种液体相同。跑步、游泳和电击的效果是相同的。大鼠通过运动（跑步和游泳）或休克诱导的获得性乙醇厌恶的成功证明，为人类酗酒者的运动和休克治疗的临床应用提供了一条途径，尽管在实际应用之前还有许多问题需要解决。
This study was planned to demonstrate rats’ acquisition of aversion to ethanol solution consumed before voluntary running, forced swimming, or electric shock delivery. Wistar rats under water deprivation were allotted to four groups of eight rats each, and all rats were allowed to drink 5% ethanol solution for 15 min. Immediately after the ethanol drinking, rats of Group Run were put into the individual running wheels for 15 min, those of Group Swim were put into the individual swimming pools for 15 min, those of Group Shock received electric shocks for 15 min (15 0.45-mA shocks of 0.7s with the intershock interval of 1 min) in the individual small chambers, and those of Group Control were directly returned back to the home cages. This procedure was repeated for six days, followed by a two-day choice test of ethanol aversion where a bottle containing 5% ethanol solution and a bottle of tap water were simultaneously presented for 15 min. In the test, Groups Run, Swim, and Shock drank ethanol solution significantly less than tap water, while Group Control drank both fluids equally. The effects of running, swimming, and shock were equivalent. The successful demonstration of acquired ethanol aversion induced by exercise (running and swimming) or shock in rats suggests an avenue for clinical application of exercise and shock treatments for human alcoholics, though there are many issues to be resolved before the practical use.