Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life: the Medical Research Council (MRC) National Survey of Health and Development
Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life: the Medical Research Council (MRC) National Survey of Health and Development
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DOI：
10.1093/ije/dyw134
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发表时间：
2016-08-01
影响因子：
7.7
通讯作者：
Ong, K. K.
中科院分区：
文献类型：
--
作者：
Cole, T. J.;Kuh, D.;Ong, K. K.
背景资料：为了探索一个测量频率较低的队列中青春期生长与后期骨骼健康之间的关联，使用另一个测量频率较高的队列来支持建模，来自医学研究理事会（MRC）全国健康与发展调查的数据（2-26岁，4901/30 004名受试者/测量）和雅芳父母和儿童纵向研究（ALSPAC）方法：采用平移旋转叠加法（SITAR）生长曲线分析方法，对NSHD数据进行分析，并与ALSPAC数据进行比较。青春期生长参数的大小，克里思和速度的改进估计进行了评估模型拟合的变化和相关性与青春期时间的当代措施。骨结果的半径[骨小梁体积骨密度（vBMD）和骨干横截面积（CSA）]回归SITAR参数，调整当前的身体size.Results：NSHD SITAR参数更好地估计与ALSPAC，即更强的相关性与青春期的时间。小梁vBMD与早期的身高克里思，而骨干CSA与体重大小，早期克里思和速度慢，骨的结果是15%左右高出更好与更差的增长pattern.Conclusions：通过汇集NSHD和ALSPAC数据，SITAR更准确地总结青春期生长和体重增加NSHD，反过来又表现出显着的青春期时间和后期骨的结果之间的关联。这些关联让我们深入了解青春期对未来骨骼健康和骨质疏松风险的重要性。
Background: To explore associations between pubertal growth and later bone health in a cohort with infrequent measurements, using another cohort with more frequent measurements to support the modelling, data from the Medical Research Council (MRC) National Survey of Health and Development (2-26 years, 4901/30 004 subjects/measurements) and the Avon Longitudinal Study of Parents And Children (ALSPAC) (5-20 years) (10 896/74 120) were related to National Survey of Health and Development (NSHD) bone health outcomes at 60-64 years.Methods: NSHD data were analysed using Super-Imposition by Translation And Rotation (SITAR) growth curve analysis, either alone or jointly with ALSPAC data. Improved estimation of pubertal growth parameters of size, tempo and velocity was assessed by changes in model fit and correlations with contemporary measures of pubertal timing. Bone outcomes of radius [trabecular volumetric bone mineral density (vBMD) and diaphysis cross-sectional area (CSA)] were regressed on the SITAR parameters, adjusted for current body size.Results: The NSHD SITAR parameters were better estimated in conjunction with ALSPAC, i.e. more strongly correlated with pubertal timing. Trabecular vBMD was associated with early height tempo, whereas diaphysis CSA was related to weight size, early tempo and slow velocity, the bone outcomes being around 15% higher for the better vs worse growth pattern.Conclusions: By pooling NSHD and ALSPAC data, SITAR more accurately summarized pubertal growth and weight gain in NSHD, and in turn demonstrated notable associations between pubertal timing and later bone outcomes. These associations give insight into the importance of the pubertal period for future skeletal health and osteoporosis risk.