Influence of silanated filler content on the biodegradation of bisGMA/TEGDMA dental composite resins
Influence of silanated filler content on the biodegradation of bisGMA/TEGDMA dental composite resins
复制标题
DOI：
10.1002/jbm.a.31004
复制
发表时间：
2007-04-01
影响因子：
4.9
通讯作者：
Santerre, J. P.
中科院分区：
文献类型：
--
作者：
Finer, Y.;Santerre, J. P.
已经表明，牙科复合材料中非硅烷化亚微米胶体二氧化硅填料颗粒含量的增加导致在与胆固醇酯酶（CE）孵育后释放更多的双酚-A二缩水甘油基二甲基丙烯酸酯（bisGMA）衍生的产物，双-羟基-丙氧基苯基丙烷。这项工作进一步研究了酶催化的精细复合树脂系统的生物降解，含有硅烷化的微米尺寸不规则的玻璃填料，通常用于临床净化。将基于双GMA/三甘醇二甲基丙烯酸酯（TEGDMA）的模型复合树脂样品（10或60%重量分数的硅烷化钡玻璃填料，1 μ m平均粒度）在缓冲液或含有CE的缓冲液（pH=7.0，37 ℃溶液）中孵育32天。使用高效液相色谱法、紫外光谱法和质谱法分析孵育溶液。两组均采用傅里叶变换红外光谱、扫描电子显微镜和X射线光电子能谱进行表征。与先前的非硅烷化的亚微米填料系统的研究结果相比，较高的填料含量的复合材料显示出其稳定性随时间的增加，暴露于酯酶后，当与较低的填料含量的材料相比。同样，60%填料复合物浸出较少的未反应单体TEGDMA。由于这里研究的模型复合树脂是相同的，只有填料含量不同，生物稳定性的差异可以具体地与树脂/填料分布的相对量相关。不同材料在不同牙科应用中的临床使用（从窝沟封闭剂到牙齿颜色的高度填充材料）必须考虑到作为填料含量的函数发生不同降解特性的可能性。(c)2006 Wiley Periodicals，Inc. J Biomed Mater Res 81 A：75-84，2007.
It has been shown that an increase in the content of nonsilanated submicron colloidal silica filler particles within dental composites resulted in the release of more bis-phenol-A diglycidyl dimethacrylate (bisGMA)derived product, bis-hydroxy-propoxyphenyl propane, following incubation with cholesterol esterase (CE). This work further investigates the enzyme-catalyzed biodegradation of fine composite resin systems, containing silanated micron-size irregular glass fillers, commonly used in clinical restorations. Model composite resin samples (10 or 60% weight fraction silanated barium glass filler, 1 mu m average particle size) based on bisGMA/triethylene glycol dimethacrylate (TEGDMA) were incubated in buffer or buffer with CE (pH=7.0, 37 degrees C solutions for 32 days. The incubation solutions were analyzed using high-performance liquid chromatography, UV spectroscopy, and mass spectrometry. Both groups were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. In contrast with previous findings for nonsilanated submicron filler systems, the higher filler containing composite showed an increase in its stability with time, following exposure to esterase and when compared to the lower filler content material. As well, the 60% filler composite leached less unreacted monomer TEGDMA. Since the model composite resins studied here were identical and only the filler content varied, the differences in biostability could be specifically associated with the relative amount of resin/filler distribution. The clinical use of different materials in varied dental applications (ranging from fissure sealant to tooth-colored highly filled materials) must consider the potential for different degradation profiles to occur as a function of filler content. (c) 2006 Wiley Periodicals, Inc. J Biomed Mater Res 81A: 75-84, 2007.