FLUNARIZINE, A CALCIUM-CHANNEL BLOCKER - A NEW PROPHYLACTIC DRUG IN MIGRAINE
FLUNARIZINE, A CALCIUM-CHANNEL BLOCKER - A NEW PROPHYLACTIC DRUG IN MIGRAINE
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DOI：
10.1111/j.1526-4610.1983.hed2302070.x
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发表时间：
1983-01-01
期刊：
影响因子：
5
通讯作者：
AMERY, WK
中科院分区：
文献类型：
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作者：
AMERY, WK
偏头痛发作和氟桂利嗪的抗缺氧特性的起源局灶性脑缺氧的假设的关键作用，导致在偏头痛的治疗中使用选择性钙离子进入阻滞剂。临床经验进行了审查。经双盲安慰剂对照研究和与吡唑替芬和桂利嗪的比较证实的开放性研究结果表明，氟桂利嗪10 mg/天是一种安全有效的预防常见和典型偏头痛的药物。对影响氟桂利嗪疗效的因素进行了讨论。
The postulated pivotal role of focal brain hypoxia in the genesis of the migraine attack and the anti-hypoxic properties of flunarizine, led to the use of the selective Ca-entry blocker in the treatment of migraine. Clinical experience is reviewed. Open findings, confirmed by double-blind placebo-controlled studies and comparisons with pizotifen and cinnarizine, showed that flunarizine 10 mg/day, is a safe and effective prophylactic drug for both common and classical migraine. Factors determining the efficacy of flunarizine are discussed.