Change of diffusion anisotropy in patients with acute cerebral infarction using statistical parametric analysis.
Change of diffusion anisotropy in patients with acute cerebral infarction using statistical parametric analysis.
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DOI：
10.1007/s11604-005-1535-z
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发表时间：
2006-05-01
影响因子：
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通讯作者：
Nishitani, Hiromu
中科院分区：
文献类型：
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作者：
Morita, Naomi;Harada, Masafumi;Nishitani, Hiromu
目得：我们进行了统计参数比较分数各向异性（FA）的图像和量化FA值，以确定是否发生显着变化，在缺血regions.MATERIALS和方法：受试者20例缺血发作后24小时内看到。对于FA图像的统计比较，通过Talairach模板协调样本FA图像，并将每个FA图归一化。使用SPM 99进行统计学比较。在表观扩散系数（ADC）和FA图上的同一区域设置感兴趣区域，该区域与扩散加权图像（DWI）上的高信号区域一致。对侧区域也进行了测量，以获得ADC和FA的不对称比率。结果：FA图像上的区域的统计学意义，发现只有在白色物质的3名患者，虽然该地区小于DWI上的高信号区。平均ADC和FA比值分别为0.64 +/- 0.16和0.93 +/- 0.09，FA变化的程度小于ADC变化的程度。扩散各向异性的显着变化仅限于严重梗死的核心的白色matter.CONCLUSION：我们相信FA地图的统计比较是有用的，用于检测不同地区的扩散各向异性。
PURPOSE: We conducted statistical parametric comparison of fractional anisotropy (FA) images and quantified FA values to determine whether significant change occurs in the ischemic region.MATERIALS AND METHODS: The subjects were 20 patients seen within 24 h after onset of ischemia. For statistical comparison of FA images, a sample FA image was coordinated by the Talairach template, and each FA map was normalized. Statistical comparison was conducted using SPM99. Regions of interest were set in the same region on apparent diffusion coefficient (ADC) and FA maps, the region being consistent with the hyperintense region on diffusion-weighted images (DWIs). The contralateral region was also measured to obtain asymmetry ratios of ADC and FA.RESULTS: Regions with areas of statistical significance on FA images were found only in the white matter of three patients, although the regions were smaller than hyperintense regions on DWIs. The mean ADC and FA ratios were 0.64 +/- 0.16 and 0.93 +/- 0.09, respectively, and the degree of FA change was less than that of the ADC change. Significant change in diffusion anisotropy was limited to the severely infarcted core of the white matter.CONCLUSION: We believe statistical comparison of FA maps to be useful for detecting different regions of diffusion anisotropy.