PATHOGENESIS AND AUTOINTERFERENCE IN A VIRUS DISEASE OF CRABS
PATHOGENESIS AND AUTOINTERFERENCE IN A VIRUS DISEASE OF CRABS
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DOI：
10.1128/iai.9.6.1057-1061.1974
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发表时间：
1974-01-01
影响因子：
3.1
通讯作者：
BANG, FB
中科院分区：
文献类型：
--
作者：
BANG, FB
感染过程显然是由海岸蟹（Carcinus maenas）血液中的一种滤过性病毒引起的，在法国罗斯科夫的两个实验室都对这种宿主进行了实验研究。它最初被发现的地方，以及马萨诸塞州的伍兹霍尔，当地物种也被发现易受感染。虽然一部分受感染的动物会因凝血功能不全而死亡，但大约三分之二的动物的凝血功能迅速恢复。有一半的动物在4到6天内恢复了这一功能。恢复并不伴随着病毒从全血中消失。在恢复后40天进行的测试中，病毒仍然存在。急性感染后出现自身干扰。在所有试验日，在明显疾病动物的血清中以及在凝血缺陷出现后2天以上采集的动物全血中均发现该物质。在疾病的前2天内，在全血中未证实。讨论了这在恢复现象中的作用。
The course of an infection apparently caused by a filterable virus of the blood of the shore crab.Carcinus maenas, has been experimentally studied in this host both at Roscoff, France. where it was originally found, and at Woods Hole, Mass., where the local species was also found susceptible. Although a portion of the infected animals die with the symptoms of inadequate blood clotting, recovery of this function occurred promptly in about two-thirds of the animals. Half of the animals that recovered this function did so within 4 to 6 days. Recovery was not accompanied by disappearance of the virus from the whole blood. In tests done as late as 40 days after recovery, virus was still present. Autointerference was demonstrated after acute infection. It was found in the serum of animals with manifest disease on all days tested and in whole blood of animals taken more than 2 days after the clotting defect appeared. It was not demonstrable within the whole blood within the first 2 days of disease. The role of this in the recovery phenomenon is discussed.