Changing trends in the distribution of the histologic types of lung cancer: a review of 4,439 cases
Changing trends in the distribution of the histologic types of lung cancer: a review of 4,439 cases
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DOI：
10.1016/j.anndiagpath.2006.04.006
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发表时间：
2007-04-01
影响因子：
2
通讯作者：
Eltorky, Mahmoud
中科院分区：
文献类型：
--
作者：
Wahbah, Mary;Boroumand, Nahal;Eltorky, Mahmoud
肺癌是第二大常见癌症，也是男性和女性癌症死亡的主要原因。本研究的目的是探讨肺癌的4种主要组织学类型的分布和肺癌的发病率，并参考所有其他部位的癌症。本文回顾了1980年1月至2003年12月4439例肺癌患者的临床和组织病理学资料。腺癌已成为男性和女性中最常见的组织学类型（分别为36.8%和46.5%），其次是鳞状细胞癌（分别为31.6%和25.4%）。男性和女性的大细胞（未分化）癌发病率分别为18.0%和9.9%。男性和女性的小细胞癌发病率分别为13.7%和18.3%。此外，我们的数据分析表明，相对于所有其他原发癌症部位，肺癌的发病率正在下降。这项研究的结果表明，与德克萨斯州南部的其他癌症来源相比，肺癌的发病率有所下降。这一观察结果与当前的国家趋势是一致的。此外，肺癌主要组织学类型的分布也有显著变化。这项研究的结果可能预示着靶向治疗的选择和患者管理的重要变化。(C) 2007爱思唯尔公司版权所有。
Lung cancer is the second most common cancer and the leading cause of cancer death in both men and women. The purpose of the study is to explore the distribution of the 4 major histologic types of lung carcinoma and the incidence of lung cancer with reference to all other sites of cancer. The clinical and histopathologic data of 4,439 patients with lung carcinoma between January 1980 and December 2003 were reviewed. Adenocarcinoma has become the most frequent histologic type in men and women (36.8% and 46.5%, respectively), followed by squamous cell carcinoma (31.6% and 25.4%, respectively). The incidence of large cell (undifferentiated) carcinoma in men and women is 18.0% and 9.9%, respectively. The incidence of small cell carcinoma in men and women is 13.7% and 18.3%, respectively. In addition, analysis of our data indicates that lung cancer rate is decreasing, relative to all other primary cancer sites. The results of this study suggest that the incidence of lung cancer has decreased in comparison with other sources of cancer in southern Texas. This observation is consistent with the current national trends. In addition, there are significant changes in the distribution of the major histologic types of lung cancer. The results of this study may portend important changes in the selection of targeted therapy and patient management. (C) 2007 Elsevier Inc. All rights reserved.