Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women
Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women
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DOI：
10.1080/07315724.2005.10719463
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发表时间：
2005-06-01
影响因子：
3.5
通讯作者：
Ilich, JZ
中科院分区：
文献类型：
--
作者：
Brownbill, RA;Petrosian, M;Ilich, JZ
目的：确定饮食共轭亚油酸（CLA）是否与绝经后妇女不同骨骼部位的骨矿物质密度（BMD）相关。方法：对136名平均年龄68.6岁的健康绝经后白种人妇女进行横断面分析。采用双能x线吸光度法（DXA）评估骨密度和软组织。利用3 d饮食记录估算能量、钙、蛋白质、脂肪、CLA及其他相关营养素。同时也记录了补充剂的使用情况。目前和过去的身体活动是通过联合邓巴全国老年人健康调查来确定的。结果：CLA （63.1 +/- 46.8 mg，平均+/- SD）是Ward三角骨密度的显著预测因子（P = 0.040），多元回归模型包含绝经年数（18.5 +/- 8.4 y）、瘦肉组织、能量摄入（1691 +/- 382 kcal/天）、膳食钙（873 +/- 365 mg）、蛋白质（70.6 +/- 18.6 g）、脂肪（57.9 +/- 23.9 g）、锌（19.2 +/- 13.6 mg）和当前和过去的身体活动，R-adj = 0.286。受试者也被分为低于（1组）和高于（2组）CLA中位摄入量的组。2组患者前臂骨密度较高（p = 0.042），髋部、腰椎及全身骨密度均较高，但差异无统计学意义。结论：这些发现表明膳食CLA可能对绝经后妇女的骨密度有积极的影响。需要更多的研究来检验膳食CLA和骨密度之间的关系。
Objective: To determine if dietary conjugated linoleic acid (CLA) is associated with bone mineral density (BMD) of different skeletal sites in postmenopausal women.Methods: A cross-sectional analysis in 136 Caucasian, healthy, postmenopausal women, mean age 68.6 years. BMD and soft tissue were assessed by dual energy x-ray abosorptiometry (DXA). Energy, calcium, protein, fat, CLA and other relevant nutrients were estimated using 3 day dietary records. Supplement use was recorded as well. Current and past physical activity were determined using the Allied Dunbar National Fitness Survey for older adults.Results: CLA (63.1 +/- 46.8 mg, mean +/- SD) was a significant predictor of Ward's triangle BMD (P = 0.040) in a multiple regression model containing years since menopause (18.5 +/- 8.4 y), lean tissue, energy intake (1691 +/- 382 kcal/day) dietary calcium (873 +/- 365 mg), protein (70.6 +/- 18.6 g), fat (57.9 +/- 23.9 g), zinc (19.2 +/- 13.6 mg), and current and past physical activity, with R-adj(2) = 0.286. Subjects were also divided into groups below (Group 1) and above (Group 2) the median intake for CLA. Group 2 had higher BMD in the forearm, p = 0.042, and higher BMD in the hip, lumbar spine and whole body, however statistical significance was not reached.Conclusion: These findings indicate dietary CLA may positively benefit BMD in postmenopausal women. More studies are warranted examining the relationship between dietary CLA and BMD.